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Efficacy and Tolerability of Telaprevir for Chronic Hepatitis Virus C Genotype 1 Infection: A Meta-Analysis

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  • Yuan Kong
  • Xiaoping Wang
  • Yushu Shang
  • Paul M Schroder
  • Wenhua Liang
  • Xiaoting Ling
  • Zhiyong Guo
  • Xiaoshun He

Abstract

Background: Chronic hepatitis C virus (HCV) infection is one of the leading causes of hepatic cirrhosis and hepatocellular carcinoma, and HCV genotype 1 is the most prevalent genotype and is resistant to current standard therapy. We performed this meta-analysis to evaluate the efficacy and safety of telaprevir-based therapy for chronic HCV genotype 1 infection. Methods: We included randomized controlled trials with no year or language restriction. All data were analyzed using a random-effects model by Review Manager v5.0. The primary outcome was the proportion of patients achieving sustained virologic response (SVR), and the secondary outcomes were HCV relapse rate, incidence of severe adverse events (SAEs), and discontinuation due to adverse events. Results: The proportion of achieving SVR was significantly higher in the telaprevir group (odds ratio [OR] = 3.40 [1.92, 6.00], P

Suggested Citation

  • Yuan Kong & Xiaoping Wang & Yushu Shang & Paul M Schroder & Wenhua Liang & Xiaoting Ling & Zhiyong Guo & Xiaoshun He, 2012. "Efficacy and Tolerability of Telaprevir for Chronic Hepatitis Virus C Genotype 1 Infection: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-11, December.
    • Handle: RePEc:plo:pone00:0052158
    DOI: 10.1371/journal.pone.0052158
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