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Interactions between Serum Vitamin D Levels and Vitamin D Receptor Gene FokI Polymorphisms for Renal Function in Patients with Type 2 Diabetes

Author

Listed:
  • Keitaro Yokoyama
  • Akio Nakashima
  • Mitsuyoshi Urashima
  • Hiroaki Suga
  • Takeshi Mimura
  • Yasuo Kimura
  • Yasushi Kanazawa
  • Tamotsu Yokota
  • Masaya Sakamoto
  • Sho Ishizawa
  • Rimei Nishimura
  • Hideaki Kurata
  • Yudo Tanno
  • Katsuyoshi Tojo
  • Shigeru Kageyama
  • Ichiro Ohkido
  • Kazunori Utsunomiya
  • Tatsuo Hosoya

Abstract

Background: We aimed to examine associations among serum 25-hydroxyvitamin D (25OHD) levels, 1,25-dihyroxyvitamin D (1,25OHD) levels, vitamin D receptor (VDR) polymorphisms, and renal function based on estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes. Methods: In a cross-sectional study of 410 patients, chronic kidney disease (CKD) stage assessed by eGFR was compared with 25OHD, 1,25OHD, and VDR FokI (rs10735810) polymorphisms by an ordered logistic regression model adjusted for the following confounders: disease duration, calendar month, use of angiotensin converting enzyme inhibitors/angiotensin receptor blockers or statins, and serum calcium, phosphate, and intact parathyroid hormone levels. Results: 1,25OHD levels, rather than 25OHD levels, showed seasonal oscillations; peak levels were seen from May to October and the lowest levels were seen from December to February. These findings were evident in patients with CKD stage 3∼5 but not stage 1∼2. eGFR was in direct proportion to both 25OHD and 1,25OHD levels (P

Suggested Citation

  • Keitaro Yokoyama & Akio Nakashima & Mitsuyoshi Urashima & Hiroaki Suga & Takeshi Mimura & Yasuo Kimura & Yasushi Kanazawa & Tamotsu Yokota & Masaya Sakamoto & Sho Ishizawa & Rimei Nishimura & Hideaki , 2012. "Interactions between Serum Vitamin D Levels and Vitamin D Receptor Gene FokI Polymorphisms for Renal Function in Patients with Type 2 Diabetes," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-6, December.
    • Handle: RePEc:plo:pone00:0051171
    DOI: 10.1371/journal.pone.0051171
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