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Differentiating Non-Motor Symptoms in Parkinson's Disease from Controls and Hemifacial Spasm

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  • Ming-Hui Yong
  • John C Allen Jr
  • Kumar M Prakash
  • Eng-King Tan

Abstract

Background and Aims: Non-motor symptoms (NMS) are important manifestations of Parkinson's disease (PD) that reduce patients' health-related quality of life. Some NMS may also be caused by age-related changes, or manifested as a psychological reaction to a chronic neurological condition. This case-control study compared the NMS burden among PD patients, healthy controls and hemifacial spasm (HFS) patients. In addition, we determined the NMS that discriminated between PD and non-PD subjects. Methods: 425 subjects were recruited from a tertiary hospital in Singapore (200 PD patients, 150 healthy controls and 75 HFS patients). NMS burden in subjects was measured using the Non-Motor Symptoms Scale (NMSS). Results: NMSS total score was significantly higher in PD patients (37.9±2.6) compared to healthy controls (11.2±0.9) (p

Suggested Citation

  • Ming-Hui Yong & John C Allen Jr & Kumar M Prakash & Eng-King Tan, 2013. "Differentiating Non-Motor Symptoms in Parkinson's Disease from Controls and Hemifacial Spasm," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-7, February.
    • Handle: RePEc:plo:pone00:0049596
    DOI: 10.1371/journal.pone.0049596
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