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Higher Blood 25(OH)D Level May Reduce the Breast Cancer Risk: Evidence from a Chinese Population Based Case-Control Study and Meta-Analysis of the Observational Studies

Author

Listed:
  • Peizhan Chen
  • Mian Li
  • Xiaoli Gu
  • Yanling Liu
  • Xiaoguang Li
  • Chenglin Li
  • Yuan Wang
  • Dong Xie
  • Fudi Wang
  • Chen Yu
  • Jingquan Li
  • Xinlei Chen
  • Ruiai Chu
  • Jianmin Zhu
  • Zhouluo Ou
  • Hui Wang

Abstract

Experimental data suggest a protective effect of vitamin D on breast cancer; however, epidemiologic results remain inclusive. With a Chinese population-based case-control study and meta-analysis of the observational studies, we here systematically evaluated the association of blood 25(OH)D level and breast cancer risk. With 593 breast cancer cases and 580 cancer-free controls from Shanghai, China, we found that 80% of the normal women had severe vitamin D deficiency (less than 20 ng/mL) and 15.2% had mild deficiency (20 to 30 ng/mL) and only 4.8% of women had sufficient vitamin D level (>30 ng/mL) while the proportion was 96.1%, 3.2% and 0.7% respectively for the breast cancer patients. Compared to those with the lowest quartile of plasma 25(OH)D level, women with highest quartile 25(OH)D level showed a significant decreased breast cancer risk (Q4 vs.Q1: OR = 0.10, 95% CI = 0.06–0.15) and every 1 ng/ml increment of plasma 25(OH)D level led to a 16% lower odds of breast cancer (OR = 0.84, 95% CI = 0.81–0.87; P

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  • Peizhan Chen & Mian Li & Xiaoli Gu & Yanling Liu & Xiaoguang Li & Chenglin Li & Yuan Wang & Dong Xie & Fudi Wang & Chen Yu & Jingquan Li & Xinlei Chen & Ruiai Chu & Jianmin Zhu & Zhouluo Ou & Hui Wang, 2013. "Higher Blood 25(OH)D Level May Reduce the Breast Cancer Risk: Evidence from a Chinese Population Based Case-Control Study and Meta-Analysis of the Observational Studies," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-10, January.
    • Handle: RePEc:plo:pone00:0049312
    DOI: 10.1371/journal.pone.0049312
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