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Difference in agr Dysfunction and Reduced Vancomycin Susceptibility between MRSA Bacteremia Involving SCCmec Types IV/IVa and I–III

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  • Hee-Chang Jang
  • Seung-Ji Kang
  • Su-Mi Choi
  • Kyung-Hwa Park
  • Jong-Hee Shin
  • Hyon E Choy
  • Sook-In Jung
  • Hong Bin Kim

Abstract

Background: Dysfunction of agr, with reduced susceptibility or hetero-resistance to vancomycin, is thought to be associated with a worse outcome of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (MRSAB). However, the difference in agr dysfunction according to the SCCmec type in MRSA infection is undetermined. We compared the prevalence of agr dysfunction, reduced vancomycin susceptibility and the outcomes of SCCmec IV/IVa and I–III MRSAB. Methods: The study included 307 cases of MRSAB. SCCmec types were determined by multiplex PCR. The clinical and microbiological features and outcomes of 58 SCCmec IV/IVa MRSAB were compared with those of 249 SCCmec I–III MRSAB. Results: Compared with SCCmec I–III MRSAB, SCCmec IV/IVa MRSAB was associated with lower rates of agr dysfunction (3% vs. 43%), vancomycin minimum inhibitory concentration (MIC) = 2 µg/mL (3% vs. 15%), and hetero-resistance to vancomycin (0% vs. 8%) (all P

Suggested Citation

  • Hee-Chang Jang & Seung-Ji Kang & Su-Mi Choi & Kyung-Hwa Park & Jong-Hee Shin & Hyon E Choy & Sook-In Jung & Hong Bin Kim, 2012. "Difference in agr Dysfunction and Reduced Vancomycin Susceptibility between MRSA Bacteremia Involving SCCmec Types IV/IVa and I–III," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-7, November.
    • Handle: RePEc:plo:pone00:0049136
    DOI: 10.1371/journal.pone.0049136
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