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Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14

Author

Listed:
  • Ana Eugenia Rodríguez
  • Jose Ángel Hernández
  • Rocío Benito
  • Norma C Gutiérrez
  • Juan Luis García
  • María Hernández-Sánchez
  • Alberto Risueño
  • M Eugenia Sarasquete
  • Encarna Fermiñán
  • Rosa Fisac
  • Alfonso García de Coca
  • Guillermo Martín-Núñez
  • Natalia de las Heras
  • Isabel Recio
  • Oliver Gutiérrez
  • Javier De Las Rivas
  • Marcos González
  • Jesús M Hernández-Rivas

Abstract

Background: Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. Design and Methods:: A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors. Results: Chronic lymphocytic leukemia patients with higher percentages of 13q- cells (>80%) showed a different level of gene expression as compared to patients with lower percentages (

Suggested Citation

  • Ana Eugenia Rodríguez & Jose Ángel Hernández & Rocío Benito & Norma C Gutiérrez & Juan Luis García & María Hernández-Sánchez & Alberto Risueño & M Eugenia Sarasquete & Encarna Fermiñán & Rosa Fisac & , 2012. "Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0048485
    DOI: 10.1371/journal.pone.0048485
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