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Effects and Safety of Calcimimetics in End Stage Renal Disease Patients with Secondary Hyperparathyroidism: A Meta-Analysis

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  • Qian Zhang
  • Ming Li
  • Li You
  • Haiming Li
  • Li Ni
  • Yong Gu
  • Chuanming Hao
  • Jing Chen

Abstract

Purpose: Secondary hyperparathyroidism (SHPT) is one of the most common abnormalities of mineral metabolism in patients with chronic kidney disease. We performed a meta-analysis to determine the effect and safety of cinacalcet in SHPT patients receiving dialysis. Methods: The meta-analysis was performed to determine the effect and safety of cinacalcet in SHPT patients receiving dialysis by using the search terms ‘cinacalcet’ or ‘mimpara’ or ‘sensipar’ or ‘calcimimetic’ or ‘R586’ on MEDLINE and EMBASE (January 1990 to February 2012). Results: Fifteen trials were included, all of which were performed between 2000 and 2011 enrolling a total of 3387 dialysis patients. Our study showed that calcimimetic agents effectively ameliorated iPTH levels(WMD, −294.36 pg/mL; 95% CI, −322.76 to −265.95, P

Suggested Citation

  • Qian Zhang & Ming Li & Li You & Haiming Li & Li Ni & Yong Gu & Chuanming Hao & Jing Chen, 2012. "Effects and Safety of Calcimimetics in End Stage Renal Disease Patients with Secondary Hyperparathyroidism: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-8, October.
    • Handle: RePEc:plo:pone00:0048070
    DOI: 10.1371/journal.pone.0048070
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