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Outcomes of Sustained-Release Formulation of Valproate and Topiramate Monotherapy in Patients with Epilepsy: A Multi-Centre, Cohort Study

Author

Listed:
  • Yida Hu
  • Xishun Huang
  • Dinglie Shen
  • Meiping Ding
  • Hongbin Sun
  • Bin Peng
  • Xiangshu Hu
  • Hua Li
  • Kebin Zeng
  • Zhiqin Xi
  • Ying Zhang
  • Qingqing Cao
  • Jing Liu
  • Yan Zhou
  • Mengjiao Wu
  • Yaodong Lu
  • Guojun Chen
  • Xuefeng Wang

Abstract

Background: New-generation antiepileptic drugs (AEDs) tend to replace traditional AEDs as the first-line choice for epilepsy. However, whether this change results in better outcome, especially in China, remains unknown. Methodology/Principal Findings: Two broad spectrum AEDs, the traditional drug of sustained-release formulation of valproate (SRVPA) and the new-generation drug of topiramate, were compared in patients with epilepsy as monotherapy in this multi-centre, observational cohort study from 2000 to 2011. The primary outcome was time to treatment failure. The secondary outcomes included time to first seizure, time to 12-month remission, and time to 24-month remission. Drug tolerability was assessed. Cox proportional hazard models (95% confidence interval [CI]) were used to analyse the relative risks expressed as hazard ratios (HR). Conclusions: The SRVPA is more suitable than topiramate for Chinese epileptic patients, and our results support the viewpoint that traditional AEDs should be the first-line choice for epilepsy rather than new-generation AEDs.

Suggested Citation

  • Yida Hu & Xishun Huang & Dinglie Shen & Meiping Ding & Hongbin Sun & Bin Peng & Xiangshu Hu & Hua Li & Kebin Zeng & Zhiqin Xi & Ying Zhang & Qingqing Cao & Jing Liu & Yan Zhou & Mengjiao Wu & Yaodong , 2012. "Outcomes of Sustained-Release Formulation of Valproate and Topiramate Monotherapy in Patients with Epilepsy: A Multi-Centre, Cohort Study," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-10, December.
    • Handle: RePEc:plo:pone00:0047982
    DOI: 10.1371/journal.pone.0047982
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