IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0047588.html
   My bibliography  Save this article

Modeling 18F-FDG Kinetics during Acute Lung Injury: Experimental Data and Estimation Errors

Author

Listed:
  • A Susanne Dittrich
  • Tilo Winkler
  • Tyler Wellman
  • Nicolas de Prost
  • Guido Musch
  • R Scott Harris
  • Marcos F Vidal Melo

Abstract

Background: There is increasing interest in Positron Emission Tomography (PET) of 2-deoxy-2-[18F]flouro-D-glucose (18F-FDG) to evaluate pulmonary inflammation during acute lung injury (ALI). We assessed the effect of extra-vascular lung water on estimates of 18F-FDG-kinetics parameters in experimental and simulated data using the Patlak and Sokoloff methods, and our recently proposed four-compartment model. Methodology/Principal Findings: Eleven sheep underwent unilateral lung lavage and 4 h mechanical ventilation. Five sheep received intravenous endotoxin (10 ng/kg/min). Dynamic 18F-FDG PET was performed at the end of the 4 h period. 18F-FDG net uptake rate (Ki), phosphorylation rate (k3), and volume of distribution (Fe) were estimated in three isogravitational regions for each method. Simulations of normal and ALI 18F-FDG-kinetics were conducted to study the dependence of estimated parameters on the transport rate constants to (k5) and from (k6) the extra-vascular extra-cellular compartment. The four-compartment model described 85.7% of the studied 18F-FDG-kinetics better than the Sokoloff model. Relative to the four-compartment model the Sokoloff model exhibited a consistent positive bias in Ki (3.32 [1.30–5.65] 10−4/min, p

Suggested Citation

  • A Susanne Dittrich & Tilo Winkler & Tyler Wellman & Nicolas de Prost & Guido Musch & R Scott Harris & Marcos F Vidal Melo, 2012. "Modeling 18F-FDG Kinetics during Acute Lung Injury: Experimental Data and Estimation Errors," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-12, October.
    • Handle: RePEc:plo:pone00:0047588
    DOI: 10.1371/journal.pone.0047588
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047588
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0047588&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0047588?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0047588. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.