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Antenatal Screening for Down Syndrome Using Serum Placental Growth Factor with the Combined, Quadruple, Serum Integrated and Integrated Tests

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  • Nicholas J Wald
  • Jonathan P Bestwick
  • Lynne M George
  • Wayne J Huttly

Abstract

Objective: To estimate the value of first or second trimester placental growth factor (PlGF) as an additional antenatal screening marker for Down syndrome. Design: Nested case-control study. Setting: Antenatal screening service. Population or Sample: 532 Down syndrome pregnancies and 1,155 matched unaffected pregnancies. Methods: Stored maternal serum samples (−40°C) were assayed for PlGF. Monte Carlo simulation was used to estimate the screening performance of PlGF with the Combined, Quadruple, serum Integrated and Integrated tests. Main Outcome Measures: Median PlGF levels in affected and unaffected pregnancies and screening performance (detection rates [DR] for specified false-positive rates [FPR] and vice versa). Results: First trimester median PlGF was 15%, 28% and 39% lower in Down syndrome than unaffected pregnancies at 11, 12 and 13 completed weeks’ gestation respectively (all p

Suggested Citation

  • Nicholas J Wald & Jonathan P Bestwick & Lynne M George & Wayne J Huttly, 2012. "Antenatal Screening for Down Syndrome Using Serum Placental Growth Factor with the Combined, Quadruple, Serum Integrated and Integrated Tests," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-9, October.
    • Handle: RePEc:plo:pone00:0046955
    DOI: 10.1371/journal.pone.0046955
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