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Increasing Blood Glucose Variability Is a Precursor of Sepsis and Mortality in Burned Patients

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  • Alexander N Pisarchik
  • Olga N Pochepen
  • Liudmila A Pisarchyk

Abstract

High glycemic variability, rather than a mean glucose level, is an important factor associated with sepsis and hospital mortality in critically ill patients. In this retrospective study we analyze the blood glucose data of 172 nondiabetic patients 18–60 yrs old with second and third-degree burns of total body surface area greater than 30% and 5%, respectively, admitted to ICU in 2004–2008. The analysis identified significant association of increasing daily glucose excursion (DELTA) accompanied by evident episodes of hyperglycemia (>11 mmol/l) and hypoglycemia (

Suggested Citation

  • Alexander N Pisarchik & Olga N Pochepen & Liudmila A Pisarchyk, 2012. "Increasing Blood Glucose Variability Is a Precursor of Sepsis and Mortality in Burned Patients," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-8, October.
    • Handle: RePEc:plo:pone00:0046582
    DOI: 10.1371/journal.pone.0046582
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