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ZNF385B and VEGFA Are Strongly Differentially Expressed in Serous Ovarian Carcinomas and Correlate with Survival

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  • Bente Vilming Elgaaen
  • Ole Kristoffer Olstad
  • Leiv Sandvik
  • Elin Ødegaard
  • Torill Sauer
  • Anne Cathrine Staff
  • Kaare M Gautvik

Abstract

Background: The oncogenesis of ovarian cancer is poorly understood. The aim of this study was to identify mRNAs differentially expressed between moderately and poorly differentiated (MD/PD) serous ovarian carcinomas (SC), serous ovarian borderline tumours (SBOT) and superficial scrapings from normal ovaries (SNO), and to correlate these mRNAs with clinical parameters including survival. Methods: Differences in mRNA expression between MD/PD SC, SBOT and SNO were analyzed by global gene expression profiling (n = 23), validated by RT-qPCR (n = 41) and correlated with clinical parameters. Results: Thirty mRNAs differentially expressed between MD/PD SC, SBOT and SNO were selected from the global gene expression analyses, and 21 were verified (p

Suggested Citation

  • Bente Vilming Elgaaen & Ole Kristoffer Olstad & Leiv Sandvik & Elin Ødegaard & Torill Sauer & Anne Cathrine Staff & Kaare M Gautvik, 2012. "ZNF385B and VEGFA Are Strongly Differentially Expressed in Serous Ovarian Carcinomas and Correlate with Survival," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-9, September.
    • Handle: RePEc:plo:pone00:0046317
    DOI: 10.1371/journal.pone.0046317
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