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Neutrophil Gelatinase-Associated Lipocalin (NGAL) Predicts Response to Neoadjuvant Chemotherapy and Clinical Outcome in Primary Human Breast Cancer

Author

Listed:
  • Antonia Sophie Wenners
  • Keyur Mehta
  • Sibylle Loibl
  • Hyerim Park
  • Berit Mueller
  • Norbert Arnold
  • Sigrid Hamann
  • Joerg Weimer
  • Beyhan Ataseven
  • Silvia Darb-Esfahani
  • Christian Schem
  • Christoph Mundhenke
  • Fariba Khandan
  • Christoph Thomssen
  • Walter Jonat
  • Hans-Juergen Holzhausen
  • Gunther von Minckwitz
  • Carsten Denkert
  • Maret Bauer

Abstract

In our previous work we showed that NGAL, a protein involved in the regulation of proliferation and differentiation, is overexpressed in human breast cancer (BC) and predicts poor prognosis. In neoadjuvant chemotherapy (NACT) pathological complete response (pCR) is a predictor for outcome. The aim of this study was to evaluate NGAL as a predictor of response to NACT and to validate NGAL as a prognostic factor for clinical outcome in patients with primary BC. Immunohistochemistry was performed on tissue microarrays from 652 core biopsies from BC patients, who underwent NACT in the GeparTrio trial. NGAL expression and intensity was evaluated separately. NGAL was detected in 42.2% of the breast carcinomas in the cytoplasm. NGAL expression correlated with negative hormone receptor (HR) status, but not with other baseline parameters. NGAL expression did not correlate with pCR in the full population, however, NGAL expression and staining intensity were significantly associated with higher pCR rates in patients with positive HR status. In addition, strong NGAL expression correlated with higher pCR rates in node negative patients, patients with histological grade 1 or 2 tumors and a tumor size

Suggested Citation

  • Antonia Sophie Wenners & Keyur Mehta & Sibylle Loibl & Hyerim Park & Berit Mueller & Norbert Arnold & Sigrid Hamann & Joerg Weimer & Beyhan Ataseven & Silvia Darb-Esfahani & Christian Schem & Christop, 2012. "Neutrophil Gelatinase-Associated Lipocalin (NGAL) Predicts Response to Neoadjuvant Chemotherapy and Clinical Outcome in Primary Human Breast Cancer," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0045826
    DOI: 10.1371/journal.pone.0045826
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