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p53 codon 72 polymorphism and Hematological Cancer Risk: An Update Meta-Analysis

Author

Listed:
  • Yu Weng
  • Liqin Lu
  • Guorong Yuan
  • Jing Guo
  • Zhizhong Zhang
  • Xinyou Xie
  • Guangdi Chen
  • Jun Zhang

Abstract

Background: Previous studies on the association of p53 codon 72 (Arg72Pro) polymorphism with hematological malignancies risk have produced conflicting results. The purpose of this meta-analysis is to define the effect of p53 Arg72Pro polymorphism on hematological malignancies risk. Methodology/Principal Findings: Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH terms and keywords: “p53”, “codon 72” “polymorphism” and “leukemia”, or “lymphoma”, or “myeloma”, thirteen were identified as eligible articles in this meta-analysis for p53 Arg72Pro polymorphism (2,731 cases and 7, 356 controls), including nine studies on leukemia (1,266 cases and 4, 474 controls), three studies on lymphoma (1,359 cases and 2,652 controls), and one study on myeloma. The overall results suggested that p53 Arg72Pro polymorphism was not associated with hematological malignancies risk. In stratified analyses, significantly increased non-Hodgkin lymphomas risk was found in p53 Arg72Pro polymorphism heterozygote model (Arg/Pro vs. Arg/Arg: OR = 1.18, 95%CI: 1.02–1.35) and dominant model (Arg/Pro+Pro/Pro vs. Arg/Arg: OR = 1.18, 95%CI: 1.03–1.34), but no significant association was found between leukemia risk and p53 Arg72Pro polymorphism. Further studies showed no association between leukemia risk and p53 Arg72Pro polymorphism when stratified in subtypes of leukemias, ethnicities and sources of controls. Conclusions/Significance: This meta-analysis indicates that the p53 Arg72Pro polymorphism may contribute to susceptibility to non-Hodgkin lymphomas.

Suggested Citation

  • Yu Weng & Liqin Lu & Guorong Yuan & Jing Guo & Zhizhong Zhang & Xinyou Xie & Guangdi Chen & Jun Zhang, 2012. "p53 codon 72 polymorphism and Hematological Cancer Risk: An Update Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    • Handle: RePEc:plo:pone00:0045820
    DOI: 10.1371/journal.pone.0045820
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    Cited by:

    1. Lei Liu & Jinghua Jiao & Yu Wang & Dong Zhang & Jingyang Wu & Desheng Huang, 2014. "Lack of Association of the TP53BP1 Glu353Asp Polymorphism with Risk of Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-9, March.

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