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P53 Status as a Predictive Biomarker for Patients Receiving Neoadjuvant Radiation-Based Treatment: A Meta-Analysis in Rectal Cancer

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  • Min-Bin Chen
  • Xiao-Yang Wu
  • Rong Yu
  • Chen Li
  • Li-Qiang Wang
  • Wei Shen
  • Pei-Hua Lu

Abstract

Background: Numerous studies have yielded inconsistent results regarding the relationship between p53 status and the response to neoadjuvant radiation-based therapy in patients with rectal cancer. We conducted a meta-analysis to clarify the relationship between p53 status and response to radiation-based therapy in rectal cancer. Methods/Findings: A total of 30 previously published eligible studies including 1,830 cases were identified and included in this meta-analysis. Wild-type form of p53 status (low expression of p53 protein and/or wild-type p53 gene) was associated with pathologic response in rectal cancer patients who received neoadjuvant radiation-based therapy (good response: risk ratio [RR] = 1.30; 95% confidence intervals [CI] = 1.14–1.49; p

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  • Min-Bin Chen & Xiao-Yang Wu & Rong Yu & Chen Li & Li-Qiang Wang & Wei Shen & Pei-Hua Lu, 2012. "P53 Status as a Predictive Biomarker for Patients Receiving Neoadjuvant Radiation-Based Treatment: A Meta-Analysis in Rectal Cancer," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-9, September.
    • Handle: RePEc:plo:pone00:0045388
    DOI: 10.1371/journal.pone.0045388
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    Cited by:

    1. Yuan-Yi Rui & Dan Zhang & Zong-Guang Zhou & Cun Wang & Lie Yang & Yong-Yang Yu & Hai-Ning Chen, 2013. "Can K-ras Gene Mutation Be Utilized as Prognostic Biomarker for Colorectal Cancer Patients Receiving Chemotherapy? A Meta-Analysis and Systematic Review," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.

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