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Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks

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  • Paulo Shakarian
  • J Kenneth Wickiser

Abstract

We study the behavior of pathogens on host protein networks for humans and Arabidopsis - noting striking similarities. Specifically, we preform -shell decomposition analysis on these networks - which groups the proteins into various “shells” based on network structure. We observe that shells with a higher average degree are more highly targeted (with a power-law relationship) and that highly targeted nodes lie in shells closer to the inner-core of the network. Additionally, we also note that the inner core of the network is significantly under-targeted. We show that these core proteins may have a role in intra-cellular communication and hypothesize that they are less attacked to ensure survival of the host. This may explain why certain high-degree proteins are not significantly attacked.

Suggested Citation

  • Paulo Shakarian & J Kenneth Wickiser, 2012. "Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    • Handle: RePEc:plo:pone00:0045154
    DOI: 10.1371/journal.pone.0045154
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