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Mortality and Health Outcomes in HIV-Infected and HIV-Uninfected Mothers at 18–20 Months Postpartum in Zomba District, Malawi

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  • Megan Landes
  • Monique van Lettow
  • Richard Bedell
  • Isabell Mayuni
  • Adrienne K Chan
  • Lyson Tenthani
  • Erik Schouten

Abstract

Background: Maternal morbidity and mortality among HIV-infected women is a global concern. This study compared mortality and health outcomes of HIV-infected and HIV-uninfected mothers at 18–20 months postpartum within routine prevention of mother-to-child transmission of HIV (PMTCT) services in a rural district in Malawi. Methods: A retrospective cohort study of mother-child dyads at 18–20 months postpartum in Zomba District. Data on socio-demographic characteristics, service uptake, maternal health outcomes and biometric parameters were collected. Results: 173 HIV-infected and 214 HIV-uninfected mothers were included. HIV-specific cohort mortality at 18–20 months postpartum was 42.4 deaths/1000 person-years; no deaths occurred among HIV-uninfected women. Median time to death was 11 months post-partum (range 3–19). Women ranked their health on a comparative qualitative scale; HIV-infected women perceived their health to be poorer than did HIV-uninfected women (RR 2.4; 95% CI 1.6–3.7). Perceived maternal health status was well correlated with an objective measure of functional status (Karnofsky scale; p

Suggested Citation

  • Megan Landes & Monique van Lettow & Richard Bedell & Isabell Mayuni & Adrienne K Chan & Lyson Tenthani & Erik Schouten, 2012. "Mortality and Health Outcomes in HIV-Infected and HIV-Uninfected Mothers at 18–20 Months Postpartum in Zomba District, Malawi," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
  • Handle: RePEc:plo:pone00:0044396
    DOI: 10.1371/journal.pone.0044396
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