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Adverse Drug Reactions in Hospitalised Children in Germany Are Decreasing: Results of a Nine Year Cohort-Based Comparison

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  • Ann-Kathrin Oehme
  • Asia N Rashed
  • Barbara Hefele
  • Ian C K Wong
  • Wolfgang Rascher
  • Antje Neubert

Abstract

Background: In recent years, efforts have been made to improve paediatric drug therapy. The aim of this research was to investigate any changes regarding the frequency and nature of adverse drug reactions (ADRs) in hospitalized children in one paediatric general medical ward over a 9-year period. Methodology: Two prospective observational cohort studies were conducted at a large University hospital in Germany in 1999 and 2008, respectively. Children aged 0–18 years admitted to the study ward during the study periods were included. ADRs were identified using intensive chart review. Uni- and multivariable regression has been used for data analysis. Results: A total of 520 patients (574 admissions) were included [1999: n = 144 (167); 2008: n = 376 (407)]. Patients received a total of 2053 drugs [median 3, interquartile range (IQR) 2–5]. 19% of patients did not receive any medication. Median length of stay was 4 days (IQR 3–7; range 1–190 days) with a significantly longer length of stay in 1999. The overall ADR incidence was 13.1% (95% CI, 9.8–16.3) varying significantly between the two study cohorts [1999: 21.9%, 95% CI, 14.7–29.0; 2008: 9.2%, 95% CI, 5.9–12.5 (p

Suggested Citation

  • Ann-Kathrin Oehme & Asia N Rashed & Barbara Hefele & Ian C K Wong & Wolfgang Rascher & Antje Neubert, 2012. "Adverse Drug Reactions in Hospitalised Children in Germany Are Decreasing: Results of a Nine Year Cohort-Based Comparison," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-11, September.
    • Handle: RePEc:plo:pone00:0044349
    DOI: 10.1371/journal.pone.0044349
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