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Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-Analysis

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  • Chao Cao
  • Ran Wang
  • Jianmiao Wang
  • Hansvin Bunjhoo
  • Yongjian Xu
  • Weining Xiong

Abstract

Background: The association between body mass index (BMI) and mortality in patients suffering from chronic obstructive pulmonary disease (COPD) has been a subject of interest for decades. However, the evidence is inadequate to draw robust conclusions because some studies were generally small or with a short follow-up. Methods: We carried out a search in MEDLINE, Cochrane Central Register of Controlled Trials, and EMBASE database for relevant studies. Relative risks (RRs) with 95% confidence interval (CI) were calculated to assess the association between BMI and mortality in patients with COPD. In addition, a baseline risk-adjusted analysis was performed to investigate the strength of this association. Results: 22 studies comprising 21,150 participants were included in this analysis. Compared with patients having a normal BMI, underweight individuals were associated with higher mortality (RR = 1.34, 95% CI = 1.01–1.78), whereas overweight (RR = 0.47, 95% CI = 0.33–0.68) and obese (RR = 0.59, 95% CI = 0.38–0.91) patients were associated with lower mortality. We further performed a baseline risk-adjusted analysis and obtained statistically similar results. Conclusion: Our study showed that for patients with COPD being overweight or obese had a protective effect against mortality. However, the relationship between BMI and mortality in different classes of obesity needed further clarification in well-designed clinical studies.

Suggested Citation

  • Chao Cao & Ran Wang & Jianmiao Wang & Hansvin Bunjhoo & Yongjian Xu & Weining Xiong, 2012. "Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-8, August.
    • Handle: RePEc:plo:pone00:0043892
    DOI: 10.1371/journal.pone.0043892
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    Cited by:

    1. Dominika Mekal & Aleksandra Czerw & Andrzej Deptala, 2021. "Dietary Behaviour and Nutrition in Patients with COPD Treated with Long-Term Oxygen Therapy," IJERPH, MDPI, vol. 18(23), pages 1-12, December.
    2. Ji Eun Min & Da-An Huh & Kyong Whan Moon, 2020. "The Joint Effects of Some Beverages Intake and Smoking on Chronic Obstructive Pulmonary Disease in Korean Adults: Data Analysis of the Korea National Health and Nutrition Examination Survey (KNHANES),," IJERPH, MDPI, vol. 17(7), pages 1-13, April.
    3. Junga Lee & Jeffrey A Meyerhardt & Edward Giovannucci & Justin Y Jeon, 2015. "Association between Body Mass Index and Prognosis of Colorectal Cancer: A Meta-Analysis of Prospective Cohort Studies," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-25, March.

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