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Cytotoxic T-Lymphocyte Associated Antigen 4 Polymorphisms and Asthma Risk: A Meta-Analysis

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  • Wei Nie
  • Jiquan Chen
  • Qingyu Xiu

Abstract

Background: A number of studies assessed the association of cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) gene polymorphisms with asthma in different populations. However, the results were contradictory. We performed a meta-analysis to examine the association between CTLA-4 polymorphisms and asthma susceptibility. Methods: Pubmed, EMBASE, HuGE Navigator, and Wanfang Database were searched. Data were extracted independently by two reviewers. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Results: Seventeen studies involving 6378 cases and 8674 controls were included. Significant association between +49 A/G polymorphism and asthma was observed for AA vs. AG+GG (OR = 1.18, 95% CI 1.01–1.37, P = 0.04). There were no significant associations between −318 C/T, −1147 C/T, CT60 A/G, −1722 C/T, or rs926169 polymorphisms and asthma risk. Conclusions: This meta-analysis suggested that the +49 A/G polymorphism in CTLA-4 was a risk factor for asthma.

Suggested Citation

  • Wei Nie & Jiquan Chen & Qingyu Xiu, 2012. "Cytotoxic T-Lymphocyte Associated Antigen 4 Polymorphisms and Asthma Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0042062
    DOI: 10.1371/journal.pone.0042062
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    Cited by:

    1. Wei Nie & Yuansheng Zang & Jiquan Chen & Qingyu Xiu, 2013. "Association between Interleukin-4 Receptor α Chain (IL4RA) I50V and Q551R Polymorphisms and Asthma Risk: An Update Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-9, July.

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