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Concordance of Sleep and Pain Outcomes of Diverse Interventions: An Umbrella Review

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  • Anthony G Doufas
  • Orestis A Panagiotou
  • John P A Ioannidis

Abstract

Background/Objective: Pain influences sleep and vice versa. We performed an umbrella review of meta-analyses on treatments for diverse conditions in order to examine whether diverse medical treatments for different conditions have similar or divergent effects on pain and sleep. Methods: We searched published systematic reviews with meta-analyses in the Cochrane Database of Systematic Reviews until October 20, 2011. We identified randomized trials (or meta-analyses thereof, when >1 trial was available) where both pain and sleep outcomes were examined. Pain outcomes were categorized as headache, musculoskeletal, abdominal, pelvic, generic or other pain. Sleep outcomes included insomnia, sleep disruption, and sleep disturbance. We estimated odds ratios for all outcomes and evaluated the concordance in the direction of effects between sleep and various types of pain and the correlation of treatment effects between sleep and pain outcomes. Results: 151 comparisons with 385 different trials met our eligibility criteria. 96 comparisons had concordant direction of effects between each pain outcome and sleep, while in 55 the effect estimates were in opposite directions (P

Suggested Citation

  • Anthony G Doufas & Orestis A Panagiotou & John P A Ioannidis, 2012. "Concordance of Sleep and Pain Outcomes of Diverse Interventions: An Umbrella Review," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-7, July.
    • Handle: RePEc:plo:pone00:0040891
    DOI: 10.1371/journal.pone.0040891
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