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Mouse Allergen, Lung Function, and Atopy in Puerto Rican Children

Author

Listed:
  • Erick Forno
  • Michelle M Cloutier
  • Soma Datta
  • Kathryn Paul
  • Jody Sylvia
  • Deanna Calvert
  • Sherell Thornton-Thompson
  • Dorothy B Wakefield
  • John Brehm
  • Robert G Hamilton
  • María Alvarez
  • Angel Colón-Semidey
  • Edna Acosta-Pérez
  • Glorisa Canino
  • Juan C Celedón

Abstract

Objective: To examine the relation between mouse allergen exposure and asthma in Puerto Rican children. Methods: Mus m 1, Der p 1, Bla g 2, and Fel d 1 allergens were measured in dust samples from homes of Puerto Rican children with (cases) and without (controls) asthma in Hartford, CT (n = 449) and San Juan (SJ), Puerto Rico (n = 678). Linear or logistic regression was used for the multivariate analysis of mouse allergen (Mus m 1) and lung function (FEV1 and FEV1/FVC) and allergy (total IgE and skin test reactivity (STR) to ≥1 allergen) measures. Results: Homes in SJ had lower mouse allergen levels than those in Hartford. In multivariate analyses, mouse allergen was associated with higher FEV1 in cases in Hartford (+70.6 ml, 95% confidence interval (CI) = 8.6–132.7 ml, P = 0.03) and SJ (+45.1 ml, 95% CI = −0.5 to 90.6 ml, P = 0.05). In multivariate analyses of controls, mouse allergen was inversely associated with STR to ≥1 allergen in non-sensitized children (odds ratio [OR] for each log-unit increment in Mus m 1 = 0.7, 95% CI = 0.5–0.9, P

Suggested Citation

  • Erick Forno & Michelle M Cloutier & Soma Datta & Kathryn Paul & Jody Sylvia & Deanna Calvert & Sherell Thornton-Thompson & Dorothy B Wakefield & John Brehm & Robert G Hamilton & María Alvarez & Angel , 2012. "Mouse Allergen, Lung Function, and Atopy in Puerto Rican Children," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-9, July.
    • Handle: RePEc:plo:pone00:0040383
    DOI: 10.1371/journal.pone.0040383
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