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Value of TP53 Status for Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer: A Meta-Analysis

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  • Min-Bin Chen
  • Ya-Qun Zhu
  • Jun-Ying Xu
  • Li-Qiang Wang
  • Chao-Ying Liu
  • Zhang-Yi Ji
  • Pei-Hua Lu

Abstract

Background: Numerous studies have yielded inconclusive results regarding the relationship between tumor suppressor protein TP53 overexpression and/or TP53 gene mutations and the response to neoadjuvant chemotherapy in patients with breast cancer. The purpose of the current study was therefore to evaluate the relationship between TP53 status and response to chemotherapy in breast cancer. Methods and Findings: A total of 26 previously published eligible studies including 3,476 cases were identified and included in this meta-analysis. TP53 status (over expression of TP53 protein and/or TP53 gene mutations) was associated with good response in breast cancer patients who received neoadjuvant chemotherapy (total objective response: risk ratio [RR] = 1.20, 95% confidence interval [CI] = 1.09–1.33, p

Suggested Citation

  • Min-Bin Chen & Ya-Qun Zhu & Jun-Ying Xu & Li-Qiang Wang & Chao-Ying Liu & Zhang-Yi Ji & Pei-Hua Lu, 2012. "Value of TP53 Status for Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-6, June.
    • Handle: RePEc:plo:pone00:0039655
    DOI: 10.1371/journal.pone.0039655
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    Cited by:

    1. Ailin Lan & Junru Chen & Chao Li & Yudi Jin & Yinan Wu & Yuran Dai & Linshan Jiang & Han Li & Yang Peng & Shengchun Liu, 2023. "Development and Assessment of a Novel Core Biopsy-Based Prediction Model for Pathological Complete Response to Neoadjuvant Chemotherapy in Women with Breast Cancer," IJERPH, MDPI, vol. 20(2), pages 1-16, January.

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