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Factors Associated with Tuberculosis Treatment Default in an Endemic Area of the Brazilian Amazon: A Case Control-Study

Author

Listed:
  • Marlucia da Silva Garrido
  • Maria Lucia Penna
  • Tomàs M Perez-Porcuna
  • Alexandra Brito de Souza
  • Leni da Silva Marreiro
  • Bernardino Claudio Albuquerque
  • Flor Ernestina Martínez-Espinosa
  • Samira Bührer-Sékula

Abstract

Setting: Treatment default is a serious problem in tuberculosis control because it implies persistence of infection source, increased mortality, increased relapse rates and facilitates the development of resistant strains. Objective: This study analyzed tuberculosis treatment default determinants in the Amazonas State to contribute in planning appropriate control interventions. Design: Observational study with a retrospective cohort using Brazilian Disease Notification System data from 2005 to 2010. A nested case control study design was used. Patients defaulting from treatment were considered as ‘cases’ and those completing treatment as ‘controls’. In the analysis, 11,312 tuberculosis patients were included, 1,584 cases and 9,728 controls. Results: Treatment default was observed to be associated to previous default (aOR 3.20; p

Suggested Citation

  • Marlucia da Silva Garrido & Maria Lucia Penna & Tomàs M Perez-Porcuna & Alexandra Brito de Souza & Leni da Silva Marreiro & Bernardino Claudio Albuquerque & Flor Ernestina Martínez-Espinosa & Samira B, 2012. "Factors Associated with Tuberculosis Treatment Default in an Endemic Area of the Brazilian Amazon: A Case Control-Study," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0039134
    DOI: 10.1371/journal.pone.0039134
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