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Reliability and Diagnostic Performance of CT Imaging Criteria in the Diagnosis of Tuberculous Meningitis

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  • Hugo Botha
  • Christelle Ackerman
  • Sally Candy
  • Jonathan A Carr
  • Stephanie Griffith-Richards
  • Kathleen J Bateman

Abstract

Introduction: Abnormalities on CT imaging may contribute to the diagnosis of tuberculous meningitis (TBM). Recently, an expert consensus case definition (CCD) and set of imaging criteria for diagnosing basal meningeal enhancement (BME) have been proposed. This study aimed to evaluate the sensitivity, specificity and reliability of these in a prospective cohort of adult meningitis patients. Methods: Initial diagnoses were based on the CCD, classifying patients into: ‘Definite TBM’ (microbiological confirmation), ‘Probable TBM’ (diagnostic score ≥10), ‘Possible TBM’ (diagnostic score 6–9), ‘Not TBM’ (confirmation of an alternative diagnosis) or ‘Uncertain’ (diagnostic score of

Suggested Citation

  • Hugo Botha & Christelle Ackerman & Sally Candy & Jonathan A Carr & Stephanie Griffith-Richards & Kathleen J Bateman, 2012. "Reliability and Diagnostic Performance of CT Imaging Criteria in the Diagnosis of Tuberculous Meningitis," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-8, June.
    • Handle: RePEc:plo:pone00:0038982
    DOI: 10.1371/journal.pone.0038982
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    1. Michael E. Reichenheim, 2004. "Confidence intervals for the kappa statistic," Stata Journal, StataCorp LP, vol. 4(4), pages 421-428, December.
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