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Relative Accuracy of Cervical and Anal Cytology for Detection of High Grade Lesions by Colposcope Guided Biopsy: A Cut-Point Meta-Analytic Comparison

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  • Edward R Cachay
  • Wollelaw Agmas
  • William C Mathews

Abstract

Background: We recently reported, using a receiver operating characteristic area metric, the first meta-analytic comparison of the relative accuracy of cervical and anal cytology in detecting moderate or severe histopathologic lesions by magnification directed punch biopsy. The aim of the present research was to meta-analytically examine cut-point specific operating characteristics (sensitivity, specificity) of cervical and anal cytology in detecting high grade squamous intraepithelial lesion (HSIL) histopathology by colposcope directed punch biopsy. Methodology/Principal Findings: The primary eligibility requirement was availability of tabulated cytology (normal, atypical cells of unclear significance [ASCUS], low grade squamous intraepithelial lesion, HSIL or atypical squamous cells cannot rule out high grade [ASC-H]) and biopsy (

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  • Edward R Cachay & Wollelaw Agmas & William C Mathews, 2012. "Relative Accuracy of Cervical and Anal Cytology for Detection of High Grade Lesions by Colposcope Guided Biopsy: A Cut-Point Meta-Analytic Comparison," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-5, July.
    • Handle: RePEc:plo:pone00:0038956
    DOI: 10.1371/journal.pone.0038956
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    1. Wm Christopher Mathews & Wollelaw Agmas & Edward Cachay, 2011. "Comparative Accuracy of Anal and Cervical Cytology in Screening for Moderate to Severe Dysplasia by Magnification Guided Punch Biopsy: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-9, September.
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