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Chlamydia trachomatis Incidence and Re-Infection among Young Women – Behavioural and Microbiological Characteristics

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Listed:
  • Jennifer Walker
  • Sepehr N Tabrizi
  • Christopher K Fairley
  • Marcus Y Chen
  • Catriona S Bradshaw
  • Jimmy Twin
  • Nicole Taylor
  • Basil Donovan
  • John M Kaldor
  • Kathleen McNamee
  • Eve Urban
  • Sandra Walker
  • Marian Currie
  • Hudson Birden
  • Francis Bowden
  • Jane Gunn
  • Marie Pirotta
  • Lyle Gurrin
  • Veerakathy Harindra
  • Suzanne M Garland
  • Jane S Hocking

Abstract

Background: This study aimed to estimate rates of chlamydia incidence and re-infection and to investigate the dynamics of chlamydia organism load in prevalent, incident and re-infections among young Australian women. Methods: 1,116 women aged 16 to 25 years were recruited from primary care clinics in Australia. Vaginal swabs were collected at 3 to 6 month intervals for chlamydia testing. Chlamydia organism load was measured by quantitative PCR. Results: There were 47 incident cases of chlamydia diagnosed and 1,056.34 person years of follow up with a rate of 4.4 per 100 person years (95% CI: 3.3, 5.9). Incident infection was associated with being aged 16 to 20 years [RR = 3.7 (95%CI: 1.9, 7.1)], being employed [RR = 2.4 (95%CI: 1.1, 4.9)] and having two or more new sex partners [RR = 5.5 (95%CI: 2.6, 11.7)]. Recent antibiotic use was associated with a reduced incidence [RR:0.1 (95%CI: 0.0, 0.5)]. There were 14 re-infections with a rate of 22.3 per 100 person years (95%CI: 13.2, 37.6). The median time to re-infection was 4.6 months. Organism load was higher for prevalent than incident infections (p

Suggested Citation

  • Jennifer Walker & Sepehr N Tabrizi & Christopher K Fairley & Marcus Y Chen & Catriona S Bradshaw & Jimmy Twin & Nicole Taylor & Basil Donovan & John M Kaldor & Kathleen McNamee & Eve Urban & Sandra Wa, 2012. "Chlamydia trachomatis Incidence and Re-Infection among Young Women – Behavioural and Microbiological Characteristics," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-9, May.
    • Handle: RePEc:plo:pone00:0037778
    DOI: 10.1371/journal.pone.0037778
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