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The Peripheral Blood Transcriptome Identifies the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis

Author

Listed:
  • Ivana V Yang
  • Leah G Luna
  • Jennifer Cotter
  • Janet Talbert
  • Sonia M Leach
  • Raven Kidd
  • Julia Turner
  • Nathan Kummer
  • Dolly Kervitsky
  • Kevin K Brown
  • Kathy Boon
  • Marvin I Schwarz
  • David A Schwartz
  • Mark P Steele

Abstract

Rationale: Peripheral blood biomarkers are needed to identify and determine the extent of idiopathic pulmonary fibrosis (IPF). Current physiologic and radiographic prognostic indicators diagnose IPF too late in the course of disease. We hypothesize that peripheral blood biomarkers will identify disease in its early stages, and facilitate monitoring for disease progression. Methods: Gene expression profiles of peripheral blood RNA from 130 IPF patients were collected on Agilent microarrays. Significance analysis of microarrays (SAM) with a false discovery rate (FDR) of 1% was utilized to identify genes that were differentially-expressed in samples categorized based on percent predicted DLCO and FVC. Main Measurements and Results: At 1% FDR, 1428 genes were differentially-expressed in mild IPF (DLCO >65%) compared to controls and 2790 transcripts were differentially- expressed in severe IPF (DLCO >35%) compared to controls. When categorized by percent predicted DLCO, SAM demonstrated 13 differentially-expressed transcripts between mild and severe IPF (

Suggested Citation

  • Ivana V Yang & Leah G Luna & Jennifer Cotter & Janet Talbert & Sonia M Leach & Raven Kidd & Julia Turner & Nathan Kummer & Dolly Kervitsky & Kevin K Brown & Kathy Boon & Marvin I Schwarz & David A Sch, 2012. "The Peripheral Blood Transcriptome Identifies the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0037708
    DOI: 10.1371/journal.pone.0037708
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    Cited by:

    1. Corina N. D’Alessandro-Gabazza & Taro Yasuma & Tetsu Kobayashi & Masaaki Toda & Ahmed M. Abdel-Hamid & Hajime Fujimoto & Osamu Hataji & Hiroki Nakahara & Atsuro Takeshita & Kota Nishihama & Tomohito O, 2022. "Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis," Nature Communications, Nature, vol. 13(1), pages 1-23, December.

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