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Optimised Anaesthesia to Reduce Post Operative Cognitive Decline (POCD) in Older Patients Undergoing Elective Surgery, a Randomised Controlled Trial

Author

Listed:
  • Clive Ballard
  • Emma Jones
  • Nathan Gauge
  • Dag Aarsland
  • Odd Bjarte Nilsen
  • Brian K Saxby
  • David Lowery
  • Anne Corbett
  • Keith Wesnes
  • Eirini Katsaiti
  • James Arden
  • Derek Amaoko
  • Nicholas Prophet
  • Balaji Purushothaman
  • David Green

Abstract

Background: The study determined the one year incidence of post operative cognitive decline (POCD) and evaluated the effectiveness of an intra-operative anaesthetic intervention in reducing post-operative cognitive impairment in older adults (over 60 years of age) undergoing elective orthopaedic or abdominal surgery. Methods and Trial Design: The design was a prospective cohort study with a nested randomised, controlled intervention trial, using intra-operative BiSpectral index and cerebral oxygen saturation monitoring to enable optimisation of anaesthesia depth and cerebral oxygen saturation in older adults undergoing surgery. Results: In the 52 week prospective cohort study (192 surgical patients and 138 controls), mild (χ2 = 17.9 p

Suggested Citation

  • Clive Ballard & Emma Jones & Nathan Gauge & Dag Aarsland & Odd Bjarte Nilsen & Brian K Saxby & David Lowery & Anne Corbett & Keith Wesnes & Eirini Katsaiti & James Arden & Derek Amaoko & Nicholas Prop, 2012. "Optimised Anaesthesia to Reduce Post Operative Cognitive Decline (POCD) in Older Patients Undergoing Elective Surgery, a Randomised Controlled Trial," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-9, June.
    • Handle: RePEc:plo:pone00:0037410
    DOI: 10.1371/journal.pone.0037410
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