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Second-Line Antiretroviral Therapy in a Workplace and Community-Based Treatment Programme in South Africa: Determinants of Virological Outcome

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  • Victoria Johnston
  • Katherine Fielding
  • Salome Charalambous
  • Mildred Mampho
  • Gavin Churchyard
  • Andrew Phillips
  • Alison D Grant

Abstract

Background: As antiretroviral treatment (ART) programmes in resource-limited settings mature, more patients are experiencing virological failure. Without resistance testing, deciding who should switch to second-line ART can be difficult. The consequences for second-line outcomes are unclear. In a workplace- and community-based multi-site programme, with 6-monthly virological monitoring, we describe outcomes and predictors of viral suppression on second-line, protease inhibitor-based ART. Methods: We used prospectively collected clinic data from patients commencing first-line ART between 1/1/03 and 31/12/08 to construct a study cohort of patients switched to second-line ART in the presence of a viral load (VL) ≥400 copies/ml. Predictors of VL

Suggested Citation

  • Victoria Johnston & Katherine Fielding & Salome Charalambous & Mildred Mampho & Gavin Churchyard & Andrew Phillips & Alison D Grant, 2012. "Second-Line Antiretroviral Therapy in a Workplace and Community-Based Treatment Programme in South Africa: Determinants of Virological Outcome," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0036997
    DOI: 10.1371/journal.pone.0036997
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    Cited by:

    1. Dumessa Edessa & Mekonnen Sisay & Fekede Asefa, 2019. "Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(7), pages 1-19, July.
    2. Nicholas Ekow Thomford & Doreen Mhandire & Collet Dandara & George B. Kyei, 2020. "Promoting U ndetectable Equals U ntransmittable in Sub-Saharan Africa: Implication for Clinical Practice and ART Adherence," IJERPH, MDPI, vol. 17(17), pages 1-11, August.

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