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Thiamine Diphosphate in Whole Blood, Thiamine and Thiamine Monophosphate in Breast-Milk in a Refugee Population

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  • Wolfgang Stuetz
  • Verena Ilona Carrara
  • Rose McGready
  • Sue Jean Lee
  • Hans Konrad Biesalski
  • François Henry Nosten

Abstract

Background: The provision of high doses of thiamine may prevent thiamine deficiency in the post-partum period of displaced persons. Methodology/Principal Findings: The study aimed to evaluate a supplementation regimen of thiamine mononitrate (100 mg daily) at the antenatal clinics in Maela refugee camp. Women were enrolled during antenatal care and followed after delivery. Samples were collected at 12 weeks post partum. Thiamine diphosphate (TDP) in whole blood and thiamine in breast-milk of 636 lactating women were measured. Thiamine in breast-milk consisted of thiamine monophosphate (TMP) in addition to thiamine, with a mean TMP to total thiamine ratio of 63%. Mean whole blood TDP (130 nmol/L) and total thiamine in breast-milk (755 nmol/L) were within the upper range reported for well-nourished women. The prevalence of women with low whole blood TDP (

Suggested Citation

  • Wolfgang Stuetz & Verena Ilona Carrara & Rose McGready & Sue Jean Lee & Hans Konrad Biesalski & François Henry Nosten, 2012. "Thiamine Diphosphate in Whole Blood, Thiamine and Thiamine Monophosphate in Breast-Milk in a Refugee Population," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-6, June.
    • Handle: RePEc:plo:pone00:0036280
    DOI: 10.1371/journal.pone.0036280
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