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Impact of Natalizumab on Cognitive Performances and Fatigue in Relapsing Multiple Sclerosis: A Prospective, Open-Label, Two Years Observational Study

Author

Listed:
  • Pietro Iaffaldano
  • Rosa Gemma Viterbo
  • Damiano Paolicelli
  • Guglielmo Lucchese
  • Emilio Portaccio
  • Benedetta Goretti
  • Vita Direnzo
  • Mariangela D'Onghia
  • Stefano Zoccolella
  • Maria Pia Amato
  • Maria Trojano

Abstract

Background and Objectives: Natalizumab reduces the relapse rate and magnetic resonance imaging activity in patients with Relapsing-Remitting Multiple Sclerosis (RRMS). So far the influence of natalizumab on cognitive functions and fatigue in MS remains uncertain. The aim of this prospective, open-label, observational study was to evaluate the possible effects of natalizumab on cognition and fatigue measures in RRMS patients treated for up to two years. Methods: Cognitive performances were examined by the Rao's Brief Repeatable Battery (BRB), the Stroop test (ST) and the Cognitive Impairment Index (CII), every 12 months. Patients who failed in at least 3 tests of the BRB and the ST were classified as cognitively impaired (CI). Fatigue Severity Scale (FSS) was administered every 12 months to assess patient's self-reported fatigue. One hundred and 53 patients completed 1 and 2 year-natalizumab treatment, respectively. Results: After 1 year of treatment the percentage of CI patients decreased from 29% (29/100) at baseline to 19% (19/100) (p = 0.031) and the mean baseline values of CII (13.52±6.85) and FSS (4.01±1.63) scores were significantly reduced (10.48±7.12, p

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  • Pietro Iaffaldano & Rosa Gemma Viterbo & Damiano Paolicelli & Guglielmo Lucchese & Emilio Portaccio & Benedetta Goretti & Vita Direnzo & Mariangela D'Onghia & Stefano Zoccolella & Maria Pia Amato & Ma, 2012. "Impact of Natalizumab on Cognitive Performances and Fatigue in Relapsing Multiple Sclerosis: A Prospective, Open-Label, Two Years Observational Study," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0035843
    DOI: 10.1371/journal.pone.0035843
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