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Effect of Angiogenesis Inhibitor Bevacizumab on Survival in Patients with Cancer: A Meta-Analysis of the Published Literature

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  • Yuan Su
  • Wei-Bing Yang
  • Shi Li
  • Zhi-Jian Ye
  • Huan-Zhong Shi
  • Qiong Zhou

Abstract

Bevacizumab is a recombinant humanized monoclonal antibody against vascular endothelial growth factor which has been used in conjunction with other anti-cancer agents in the treatment of patients with many cancers. It remains controversial whether bevacizumab can prolong survival in cancer patients. This meta-analysis was therefore performed to evaluate effect of bevacizumab on survival in cancer patients. PubMed, EMBASE, and Web of Science databases were searched for English-language studies of randomized controlled trials comparing bevacizumab with control therapy published through February 8, 2012. Progression-free survival, overall survival, and one-year survival rate were analyzed using random- or fixed-effects model. Thirty one assessable randomized controlled trials were identified. A significant improvement in progression-free survival in cancer patients was attributable to bevacizumab compared with control therapy (hazard ratio, 0.72; 95% confidence interval, 0.68 to 0.76; p

Suggested Citation

  • Yuan Su & Wei-Bing Yang & Shi Li & Zhi-Jian Ye & Huan-Zhong Shi & Qiong Zhou, 2012. "Effect of Angiogenesis Inhibitor Bevacizumab on Survival in Patients with Cancer: A Meta-Analysis of the Published Literature," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-1, April.
    • Handle: RePEc:plo:pone00:0035629
    DOI: 10.1371/journal.pone.0035629
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    Cited by:

    1. Huan Xia & Xiao-Juan Wang & Qiong Zhou & Huan-Zhong Shi & Zhao-Hui Tong, 2014. "Efficacy and Safety of Talc Pleurodesis for Malignant Pleural Effusion: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-9, January.
    2. Irena Ilic & Slobodan Jankovic & Milena Ilic, 2016. "Bevacizumab Combined with Chemotherapy Improves Survival for Patients with Metastatic Colorectal Cancer: Evidence from Meta Analysis," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-15, August.
    3. Xing-Lin Chen & Ying-Hong Lei & Cun-Fei Liu & Qun-Fang Yang & Pei-Yuan Zuo & Cheng-Yun Liu & Chang-Zhong Chen & Yu-Wei Liu, 2013. "Angiogenesis Inhibitor Bevacizumab Increases the Risk of Ischemic Heart Disease Associated with Chemotherapy: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
    4. Fariba Ahmadizar & N Charlotte Onland-Moret & Anthonius de Boer & Geoffrey Liu & Anke H Maitland-van der Zee, 2015. "Efficacy and Safety Assessment of the Addition of Bevacizumab to Adjuvant Therapy Agents in Cancer Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-27, September.

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