IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0031656.html
   My bibliography  Save this article

Epstein-Barr Virus Infection and Sporadic Breast Cancer Risk: A Meta-Analysis

Author

Listed:
  • Qiang Huo
  • Ning Zhang
  • Qifeng Yang

Abstract

Background: A large number of epidemiological studies have evaluated the association between Epstein-Barr virus infection and breast carcinoma risk but results have been inconsistent. Methodology: Research using the polymerase chain reaction technique for detecting the Epstein-Barr virus was selected; 24 studies and 1535 cases were reviewed. Information on the study populations, sample types, publication calendar period and histological types of breast carcinoma were collected. An unconditional logistic regression model was used to analyze potential parameters related to the Epstein-Barr virus prevalence. A Kappa test was used to evaluate the consistency in detecting different Epstein-Barr virus DNA regions. Nine studies that included control groups and 1045 breast cancer cases were adopted in this meta-analysis. Conclusions: We found that 29.32% of the patients with breast carcinoma were infected with the Epstein-Barr virus. The prevalence of Epstein-Barr was highest in Asia (35.25%) and lowest in the USA (18.27%). Statistical analysis revealed a trend that showed lobular breast carcinoma might have the strongest association with Epstein-Barr virus infection. This meta-analysis showed a significant increase in breast malignancy risk in patients testing positive for the Epstein-Barr virus (OR = 6.29, 95% CI = 2.13–18.59). This result suggests that an Epstein-Barr virus infection is statistically associated with increased breast carcinoma risk.

Suggested Citation

  • Qiang Huo & Ning Zhang & Qifeng Yang, 2012. "Epstein-Barr Virus Infection and Sporadic Breast Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-8, February.
    • Handle: RePEc:plo:pone00:0031656
    DOI: 10.1371/journal.pone.0031656
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031656
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031656&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0031656?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Roger M. Harbord & Ross J. Harris & Jonathan A. C. Sterne, 2009. "Updated tests for small-study effects in meta-analyses," Stata Journal, StataCorp LP, vol. 9(2), pages 197-210, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nick Freemantle, 2008. "Biostatistical aspects for the use of evidence based medicine in health technology assessment," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 9(1), pages 31-43, November.
    2. Catarina Gonçalves & Armando Raimundo & Ana Abreu & Jorge Bravo, 2021. "Exercise Intensity in Patients with Cardiovascular Diseases: Systematic Review with Meta-Analysis," IJERPH, MDPI, vol. 18(7), pages 1-19, March.
    3. Meng-Bo Hu & Sheng-Hua Liu & Hao-Wen Jiang & Pei-De Bai & Qiang Ding, 2014. "Obesity Affects the Biopsy-Mediated Detection of Prostate Cancer, Particularly High-Grade Prostate Cancer: A Dose-Response Meta-Analysis of 29,464 Patients," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-10, September.
    4. Allison Milner & Andrew Page & Anthony D LaMontagne, 2013. "Long-Term Unemployment and Suicide: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-6, January.
    5. Sevigny, Eric L. & Fuleihan, Brian K. & Ferdik, Frank V., 2013. "Do drug courts reduce the use of incarceration?: A meta-analysis," Journal of Criminal Justice, Elsevier, vol. 41(6), pages 416-425.
    6. Shan Liu & Qing Li & Ying Zhang & Qiushuang Li & Baodong Ye & Dijiong Wu & Li Wu & Hanti Lu & Conghua Ji, 2016. "Association of Human Leukocyte Antigen DRB1*15 and DRB1*15:01 Polymorphisms with Response to Immunosuppressive Therapy in Patients with Aplastic Anemia: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-15, September.
    7. Yuan Yuan Hu & Hua Yuan & Guang Bing Jiang & Ning Chen & Li Wen & Wei Dong Leng & Xian Tao Zeng & Yu Ming Niu, 2012. "Associations between XPD Asp312Asn Polymorphism and Risk of Head and Neck Cancer: A Meta-Analysis Based on 7,122 Subjects," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-6, April.
    8. Sanghyun Hong & W. Robert Reed, 2020. "Using Monte Carlo Experiments to Select Meta-Analytic Estimators," Working Papers in Economics 20/10, University of Canterbury, Department of Economics and Finance.
    9. Tseday Jemaneh Mekasha & Finn Tarp, 2013. "Aid and Growth: What Meta-Analysis Reveals," Journal of Development Studies, Taylor & Francis Journals, vol. 49(4), pages 564-583, April.
    10. Viechtbauer, Wolfgang, 2010. "Conducting Meta-Analyses in R with the metafor Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 36(i03).
    11. Ngamaba, Kayonda Hubert & Armitage, Christopher & Panagioti, Maria & Hodkinson, Alexander, 2020. "How closely related are financial satisfaction and subjective well-being? Systematic review and meta-analysis," Journal of Behavioral and Experimental Economics (formerly The Journal of Socio-Economics), Elsevier, vol. 85(C).
    12. Jonathan Stokes & Maria Panagioti & Rahul Alam & Kath Checkland & Sudeh Cheraghi-Sohi & Peter Bower, 2015. "Effectiveness of Case Management for 'At Risk' Patients in Primary Care: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-42, July.
    13. Tseday Jemaneh Mekasha & Finn Tarp, 2013. "Aid and Growth: What Meta-Analysis Reveals," Journal of Development Studies, Taylor & Francis Journals, vol. 49(4), pages 564-583, April.
    14. Maamar Sebri, 2014. "A meta-analysis of residential water demand studies," Environment, Development and Sustainability: A Multidisciplinary Approach to the Theory and Practice of Sustainable Development, Springer, vol. 16(3), pages 499-520, June.
    15. Marta Liliana Musskopf & Amanda Finger Stadler & Ulf ME Wikesjö & Cristiano Susin, 2022. "The minipig intraoral dental implant model: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-17, February.
    16. Mohammad O Dahl, 2020. "Brucellosis in food-producing animals in Mosul, Iraq: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-16, July.
    17. Qurat-ul-Ann, Abre-Rehmat & Mirza, Faisal Mehmood, 2020. "Meta-analysis of empirical evidence on energy poverty: The case of developing economies," Energy Policy, Elsevier, vol. 141(C).
    18. Lin Zhao & Aihua Gu & Guixiang Ji & Peng Zou & Peng Zhao & Ailin Lu, 2012. "The Association between ATM IVS 22-77 T>C and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-7, January.
    19. Sandra Jo Wilson & Emily E. Tanner‐Smith & Mark W. Lipsey & Katarzyna Steinka‐Fry & Jan Morrison, 2011. "Dropout Prevention and Intervention Programs: Effects on School Completion and Dropout among School‐aged Children and Youth," Campbell Systematic Reviews, John Wiley & Sons, vol. 7(1), pages 1-61.
    20. Yi Gong & Leida Zhang & Ping Bie & Huaizhi Wang, 2013. "Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-9, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0031656. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.