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The Heritability of Amyotrophic Lateral Sclerosis in a Clinically Ascertained United States Research Registry

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  • Thomas S Wingo
  • David J Cutler
  • Nicole Yarab
  • Crystal M Kelly
  • Jonathan D Glass

Abstract

Background: The genetic basis of amyotrophic lateral sclerosis (ALS) is not entirely clear. While there are families with rare highly penetrant mutations in Cu/Zn superoxide dismutase 1 and several other genes that cause apparent Mendelian inheritance of the disease, most ALS occurs in families without another affected individual. However, twin studies suggest that all ALS has a substantial genetic basis. Herein, we estimate the genetic contribution to ALS in a clinically ascertained case series from the United States. Methodology/Principal Findings: We used the database of the Emory ALS Center to ascertain individuals with ALS along with their family histories to determine the concordance among parents and offspring for the disease. We found that concordance for all parent–offspring pairs was low (

Suggested Citation

  • Thomas S Wingo & David J Cutler & Nicole Yarab & Crystal M Kelly & Jonathan D Glass, 2011. "The Heritability of Amyotrophic Lateral Sclerosis in a Clinically Ascertained United States Research Registry," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-5, November.
    • Handle: RePEc:plo:pone00:0027985
    DOI: 10.1371/journal.pone.0027985
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    1. Hirofumi Maruyama & Hiroyuki Morino & Hidefumi Ito & Yuishin Izumi & Hidemasa Kato & Yasuhito Watanabe & Yoshimi Kinoshita & Masaki Kamada & Hiroyuki Nodera & Hidenori Suzuki & Osamu Komure & Shinya M, 2010. "Mutations of optineurin in amyotrophic lateral sclerosis," Nature, Nature, vol. 465(7295), pages 223-226, May.
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