IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0027625.html
   My bibliography  Save this article

HIV Screening via Fourth-Generation Immunoassay or Nucleic Acid Amplification Test in the United States: A Cost-Effectiveness Analysis

Author

Listed:
  • Elisa F Long

Abstract

Background: At least 10% of the 56,000 annual new HIV infections in the United States are caused by individuals with acute HIV infection (AHI). It unknown whether the health benefits and costs of routine nucleic acid amplification testing (NAAT) are justified, given the availability of newer fourth-generation immunoassay tests. Methods: Using a dynamic HIV transmission model instantiated with U.S. epidemiologic, demographic, and behavioral data, I estimated the number of acute infections identified, HIV infections prevented, quality-adjusted life years (QALYs) gained, and the cost-effectiveness of alternative screening strategies. I varied the target population (everyone aged 15-64, injection drug users [IDUs] and men who have sex with men [MSM], or MSM only), screening frequency (annually, or every six months), and test(s) utilized (fourth-generation immunoassay only, or immunoassay followed by pooled NAAT). Results: Annual immunoassay testing of MSM reduces incidence by 9.5% and costs

Suggested Citation

  • Elisa F Long, 2011. "HIV Screening via Fourth-Generation Immunoassay or Nucleic Acid Amplification Test in the United States: A Cost-Effectiveness Analysis," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-10, November.
    • Handle: RePEc:plo:pone00:0027625
    DOI: 10.1371/journal.pone.0027625
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027625
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0027625&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0027625?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Angela B Hutchinson & Pragna Patel & Stephanie L Sansom & Paul G Farnham & Timothy J Sullivan & Berry Bennett & Peter R Kerndt & Robert K Bolan & James D Heffelfinger & Vimalanand S Prabhu & Bernard M, 2010. "Cost-Effectiveness of Pooled Nucleic Acid Amplification Testing for Acute HIV Infection after Third-Generation HIV Antibody Screening and Rapid Testing in the United States: A Comparison of Three Publ," PLOS Medicine, Public Library of Science, vol. 7(9), pages 1-10, September.
    2. Lum, P.J. & Ochoa, K.C. & Hahn, J.A. & Shafer, K.P. & Evans, J.L. & Moss, A.R., 2003. "Hepatitis B Virus Immunization among Young Injection Drug Users in San Francisco, Calif: The UFO Study," American Journal of Public Health, American Public Health Association, vol. 93(6), pages 919-923.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hrayer Aprahamian & Hadi El-Amine, 2022. "Optimal Screening of Populations with Heterogeneous Risk Profiles Under the Availability of Multiple Tests," INFORMS Journal on Computing, INFORMS, vol. 34(1), pages 150-164, January.
    2. Bert, Fabrizio & Gualano, Maria Rosaria & Biancone, Paolo & Brescia, Valerio & Camussi, Elisa & Martorana, Maria & Secinaro, Silvana & Siliquini, Roberta, 2018. "Cost-effectiveness of HIV screening in high-income countries: A systematic review," Health Policy, Elsevier, vol. 122(5), pages 533-547.
    3. Hani Serag & Isabel Clark & Cherith Naig & David Lakey & Yordanos M. Tiruneh, 2022. "Financing Benefits and Barriers to Routine HIV Screening in Clinical Settings in the United States: A Scoping Review," IJERPH, MDPI, vol. 20(1), pages 1-13, December.
    4. Lauren E Cipriano & Gregory S Zaric & Mark Holodniy & Eran Bendavid & Douglas K Owens & Margaret L Brandeau, 2012. "Cost Effectiveness of Screening Strategies for Early Identification of HIV and HCV Infection in Injection Drug Users," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-14, September.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mohamed A. Eltarkawe & Shelly L. Miller, 2018. "The Impact of Industrial Odors on the Subjective Well-Being of Communities in Colorado," IJERPH, MDPI, vol. 15(6), pages 1-24, May.
    2. Choi, Susanne Y.P. & Cheung, Yuet Wah & Chen, Kanglin, 2006. "Gender and HIV risk behavior among intravenous drug users in Sichuan Province, China," Social Science & Medicine, Elsevier, vol. 62(7), pages 1672-1684, April.
    3. George Giallouros & Katerina Pantavou & Despina Pampaka & Eirini Pavlitina & Daniele Piovani & Stefanos Bonovas & Georgios K. Nikolopoulos, 2021. "Drug Injection-Related and Sexual Behavior Changes in Drug Injecting Networks after the Transmission Reduction Intervention Project (TRIP): A Social Network-Based Study in Athens, Greece," IJERPH, MDPI, vol. 18(5), pages 1-13, March.
    4. Hani Serag & Isabel Clark & Cherith Naig & David Lakey & Yordanos M. Tiruneh, 2022. "Financing Benefits and Barriers to Routine HIV Screening in Clinical Settings in the United States: A Scoping Review," IJERPH, MDPI, vol. 20(1), pages 1-13, December.
    5. Delgado, Melvin & Lundgren, Lena M. & Deshpande, Abhijit & Lonsdale, Joya & Purington, Timothy, 2008. "The association between acculturation and needle sharing among Puerto Rican injection drug users," Evaluation and Program Planning, Elsevier, vol. 31(1), pages 83-91, February.
    6. Patria Rojas & Hui Huang & Tan Li & Gira J. Ravelo & Mariana Sanchez & Christyl Dawson & Judith Brook & Mariano Kanamori & Mario De La Rosa, 2016. "Sociocultural Determinants of Risky Sexual Behaviors among Adult Latinas: A Longitudinal Study of a Community-Based Sample," IJERPH, MDPI, vol. 13(11), pages 1-21, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0027625. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.