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The Cost-Effectiveness and Value of Information of Three Influenza Vaccination Dosing Strategies for Individuals with Human Immunodeficiency Virus

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  • Bohdan Nosyk
  • Behnam Sharif
  • Huiying Sun
  • Curtis Cooper
  • Aslam H Anis
  • on behalf of the CIHR Canadian HIV Trials Network Influenza Vaccine Research Group

Abstract

Background: Influenza vaccine immunogenicity is diminished in patients living with HIV/AIDS. We evaluated the cost-effectiveness and expected value of perfect information (EVPI) of three alternative influenza vaccine dosing strategies intended to increase immunogenicity in those patients. Methods: A randomized, multi-centered, controlled, vaccine trial was conducted at 12 CIHR Canadian HIV Trials Network sites. Three dosing strategies with seasonal, inactivated trivalent, non-adjuvanted intramuscular vaccine were used in HIV infected adults: two standard doses over 28 days (Strategy A), two double doses over 28 days (Strategy B) and a single standard dose of influenza vaccine (Strategy C), administered prior to the 2008 influenza season. The comparator in our analysis was practice in the previous year, in which 82.8% of HIV/AIDS received standard-dose vaccination (Strategy D). A Markov cohort model was developed to estimate the monthly probability of Influenza-like Illness (ILI) over one influenza season. Costs and quality-adjusted life years, extrapolated to the lifetime of the hypothetical study cohorts, were estimated in calculating incremental cost-effectiveness ratios (ICER) and EVPI in conducting further research. Results: 298 patients with median CD4 of 470 cells/µl and 76% with viral load suppression were randomized. Strategy C was the most cost-effective strategy for the overall trial population and for suppressed and unsuppressed individuals. Mean ICERs for Strategy A for unsuppressed patients could also be considered cost-effective. The level of uncertainty regarding the decision to implement strategy A versus C for unsuppressed individuals was high. The maximum acceptable cost of reducing decision uncertainty in implementing strategy A for individuals with unsuppressed pVL was $418,000 - below the cost of conducting a larger-scale trial. Conclusion: Our results do not support a policy to implement increased antigen dose or booster dosing strategies with seasonal, inactivated trivalent, non-adjuvanted intramuscular vaccine for individuals with HIV in Canada. Trial Registration: ClinicalTrials.gov NCT00764998.

Suggested Citation

  • Bohdan Nosyk & Behnam Sharif & Huiying Sun & Curtis Cooper & Aslam H Anis & on behalf of the CIHR Canadian HIV Trials Network Influenza Vaccine Research Group, 2011. "The Cost-Effectiveness and Value of Information of Three Influenza Vaccination Dosing Strategies for Individuals with Human Immunodeficiency Virus," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-11, December.
    • Handle: RePEc:plo:pone00:0027059
    DOI: 10.1371/journal.pone.0027059
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    Cited by:

    1. Levent Akın & Bérengère Macabéo & Zafer Caliskan & Serdar Altinel & Ilhan Satman, 2016. "Cost-Effectiveness of Increasing Influenza Vaccination Coverage in Adults with Type 2 Diabetes in Turkey," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-14, June.
    2. Ryan P. Scott & Alison C. Cullen & Guillaume Chabot‐Couture, 2021. "Disease Surveillance Investments and Administration: Limits to Information Value in Pakistan Polio Eradication," Risk Analysis, John Wiley & Sons, vol. 41(2), pages 273-288, February.

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