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Soluble Beta-Amyloid Precursor Protein Is Related to Disease Progression in Amyotrophic Lateral Sclerosis

Author

Listed:
  • Petra Steinacker
  • Lubin Fang
  • Jens Kuhle
  • Axel Petzold
  • Hayrettin Tumani
  • Albert C Ludolph
  • Markus Otto
  • Johannes Brettschneider

Abstract

Background: Biomarkers of disease progression in amyotrophic lateral sclerosis (ALS) could support the identification of beneficial drugs in clinical trials. We aimed to test whether soluble fragments of beta-amyloid precursor protein (sAPPα and sAPPß) correlated with clinical subtypes of ALS and were of prognostic value. Methodology/Principal Findings: In a cross-sectional study including patients with ALS (N = 68) with clinical follow-up data over 6 months, Parkinson's disease (PD, N = 20), and age-matched controls (N = 40), cerebrospinal fluid (CSF) levels of sAPPα a, sAPPß and neurofilaments (NfHSMI35) were measured by multiplex assay, Progranulin by ELISA. CSF sAPPα and sAPPß levels were lower in ALS with a rapidly-progressive disease course (p = 0.03, and p = 0.02) and with longer disease duration (p = 0.01 and p = 0.01, respectively). CSF NfHSMI35 was elevated in ALS compared to PD and controls, with highest concentrations found in patients with rapid disease progression (p

Suggested Citation

  • Petra Steinacker & Lubin Fang & Jens Kuhle & Axel Petzold & Hayrettin Tumani & Albert C Ludolph & Markus Otto & Johannes Brettschneider, 2011. "Soluble Beta-Amyloid Precursor Protein Is Related to Disease Progression in Amyotrophic Lateral Sclerosis," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-6, August.
    • Handle: RePEc:plo:pone00:0023600
    DOI: 10.1371/journal.pone.0023600
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    Cited by:

    1. Zhouwei Xu & Robert David Henderson & Michael David & Pamela Ann McCombe, 2016. "Neurofilaments as Biomarkers for Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-18, October.

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