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Renal Safety of a Tenofovir-Containing First Line Regimen: Experience from an Antiretroviral Cohort in Rural Lesotho

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Listed:
  • Helen Bygrave
  • Katharina Kranzer
  • Katherine Hilderbrand
  • Guillaume Jouquet
  • Eric Goemaere
  • Nathalie Vlahakis
  • Laura Triviño
  • Lipontso Makakole
  • Nathan Ford

Abstract

Introduction: Current guidelines contraindicate TDF use when creatinine clearance (CrCl) falls below 50 ml/min. We report prevalence of abnormal renal function at baseline and factors associated with abnormal renal function from a community cohort in Lesotho. Methods: We calculated changes in CrCl from baseline for patients initiated on TDF at 6 and 12 months and the proportion of patients initiated on TDF who developed renal impairment. Screening algorithms were developed using risk factors determined by multivariate analysis. Results: Among 933 adults for whom baseline creatinine was available, 176 (18.9%) presented with a baseline CrCl

Suggested Citation

  • Helen Bygrave & Katharina Kranzer & Katherine Hilderbrand & Guillaume Jouquet & Eric Goemaere & Nathalie Vlahakis & Laura Triviño & Lipontso Makakole & Nathan Ford, 2011. "Renal Safety of a Tenofovir-Containing First Line Regimen: Experience from an Antiretroviral Cohort in Rural Lesotho," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-5, March.
    • Handle: RePEc:plo:pone00:0017609
    DOI: 10.1371/journal.pone.0017609
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    Cited by:

    1. Viktor von Wyl & Valentina Cambiano & Michael R Jordan & Silvia Bertagnolio & Alec Miners & Deenan Pillay & Jens Lundgren & Andrew N Phillips, 2012. "Cost-Effectiveness of Tenofovir Instead of Zidovudine for Use in First-Line Antiretroviral Therapy in Settings without Virological Monitoring," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-11, August.
    2. Yewulsew Mekuria & Daniel Yilma & Zeleke Mekonnen & Tesfaye Kassa & Lealem Gedefaw, 2016. "Renal Function Impairment and Associated Factors among HAART Naïve and Experienced Adult HIV Positive Individuals in Southwest Ethiopia: A Comparative Cross Sectional Study," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-11, August.
    3. Sabelo Bonginkosi Dlamini & Ming-Tsang Wu & Hans-Uwe Dahms, 2022. "Factors Associated with Antiretroviral Therapy Toxicity Out-Comes in Patients with and without Hypertension," IJERPH, MDPI, vol. 19(17), pages 1-18, September.
    4. Takeshi Nishijima & Hiroyuki Gatanaga & Hirokazu Komatsu & Kunihisa Tsukada & Takuro Shimbo & Takahiro Aoki & Koji Watanabe & Ei Kinai & Haruhito Honda & Junko Tanuma & Hirohisa Yazaki & Miwako Honda , 2012. "Renal Function Declines More in Tenofovir- than Abacavir-Based Antiretroviral Therapy in Low-Body Weight Treatment-Naïve Patients with HIV Infection," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-8, January.

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