IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0017554.html
   My bibliography  Save this article

Residual Beta Cell Function in Newly Diagnosed Type 1 Diabetes after Treatment with Atorvastatin: The Randomized DIATOR Trial

Author

Listed:
  • Stephan Martin
  • Christian Herder
  • Nanette C Schloot
  • Wolfgang Koenig
  • Tim Heise
  • Lutz Heinemann
  • Hubert Kolb
  • on behalf of the DIATOR Study Group

Abstract

Background: Recent evidence suggests that the lipid-lowering agent atorvastatin is also a potent immunomodulator. The aim of this study was to investigate the possible effect of atorvastatin on the decline of residual beta cell function in recent-onset type 1 diabetes. Methods and Findings: The randomised placebo-controlled Diabetes and Atorvastatin (DIATOR) Trial included 89 patients with newly diagnosed type 1 diabetes and islet autoantibodies (mean age 30 years, 40% females), in 12 centres in Germany. Patients received placebo or 80 mg/d atorvastatin for 18 months. As primary outcome stimulated serum C-peptide levels were determined 90 min after a standardized liquid mixed meal. An intent-to-treat analysis was performed. Fasting and stimulated C-peptide levels were not significantly different between groups at 18 months. However, median fasting serum C-peptide levels dropped from baseline to 12 and 18 months in the placebo group (from 0. 34 to 0.23 and 0.20 nmol/l, p

Suggested Citation

  • Stephan Martin & Christian Herder & Nanette C Schloot & Wolfgang Koenig & Tim Heise & Lutz Heinemann & Hubert Kolb & on behalf of the DIATOR Study Group, 2011. "Residual Beta Cell Function in Newly Diagnosed Type 1 Diabetes after Treatment with Atorvastatin: The Randomized DIATOR Trial," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-8, March.
    • Handle: RePEc:plo:pone00:0017554
    DOI: 10.1371/journal.pone.0017554
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017554
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017554&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0017554?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Friedemann Paul & Sonia Waiczies & Jens Wuerfel & Judith Bellmann-Strobl & Jan Dörr & Helmar Waiczies & Mareile Haertle & Klaus D Wernecke & Hans-Dieter Volk & Orhan Aktas & Frauke Zipp, 2008. "Oral High-Dose Atorvastatin Treatment in Relapsing-Remitting Multiple Sclerosis," PLOS ONE, Public Library of Science, vol. 3(4), pages 1-9, April.
    2. Sawsan Youssef & Olaf Stüve & Juan C. Patarroyo & Pedro J. Ruiz & Jennifer L. Radosevich & Eun Mi Hur & Manuel Bravo & Dennis J. Mitchell & Raymond A. Sobel & Lawrence Steinman & Scott S. Zamvil, 2002. "The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease," Nature, Nature, vol. 420(6911), pages 78-84, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jaime Gonzalez Cardona & Matthew D Smith & Jingya Wang & Leslie Kirby & Jason T Schott & Todd Davidson & Jodi L Karnell & Katharine A Whartenby & Peter A Calabresi, 2019. "Quetiapine has an additive effect to triiodothyronine in inducing differentiation of oligodendrocyte precursor cells through induction of cholesterol biosynthesis," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-19, September.
    2. Nick Bansback & Roberta Ara & Sue Ward & Aslam Anis & Hyon Choi, 2009. "Statin Therapy in Rheumatoid Arthritis," PharmacoEconomics, Springer, vol. 27(1), pages 25-37, January.
    3. Chien-Cheng Chien & Po-Huang Chen & Chi-Hsiang Chung & Chien-An Sun & Wu-Chien Chien & Ke-Hung Chien, 2021. "Association between Statins and Retinal Vascular Occlusion: A Population-Based Cohort Study," IJERPH, MDPI, vol. 18(18), pages 1-11, September.
    4. Friedemann Paul & Sonia Waiczies & Jens Wuerfel & Judith Bellmann-Strobl & Jan Dörr & Helmar Waiczies & Mareile Haertle & Klaus D Wernecke & Hans-Dieter Volk & Orhan Aktas & Frauke Zipp, 2008. "Oral High-Dose Atorvastatin Treatment in Relapsing-Remitting Multiple Sclerosis," PLOS ONE, Public Library of Science, vol. 3(4), pages 1-9, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0017554. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.