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Residual Beta Cell Function in Newly Diagnosed Type 1 Diabetes after Treatment with Atorvastatin: The Randomized DIATOR Trial

Author

Listed:
  • Stephan Martin
  • Christian Herder
  • Nanette C Schloot
  • Wolfgang Koenig
  • Tim Heise
  • Lutz Heinemann
  • Hubert Kolb
  • on behalf of the DIATOR Study Group

Abstract

Background: Recent evidence suggests that the lipid-lowering agent atorvastatin is also a potent immunomodulator. The aim of this study was to investigate the possible effect of atorvastatin on the decline of residual beta cell function in recent-onset type 1 diabetes. Methods and Findings: The randomised placebo-controlled Diabetes and Atorvastatin (DIATOR) Trial included 89 patients with newly diagnosed type 1 diabetes and islet autoantibodies (mean age 30 years, 40% females), in 12 centres in Germany. Patients received placebo or 80 mg/d atorvastatin for 18 months. As primary outcome stimulated serum C-peptide levels were determined 90 min after a standardized liquid mixed meal. An intent-to-treat analysis was performed. Fasting and stimulated C-peptide levels were not significantly different between groups at 18 months. However, median fasting serum C-peptide levels dropped from baseline to 12 and 18 months in the placebo group (from 0. 34 to 0.23 and 0.20 nmol/l, p

Suggested Citation

  • Stephan Martin & Christian Herder & Nanette C Schloot & Wolfgang Koenig & Tim Heise & Lutz Heinemann & Hubert Kolb & on behalf of the DIATOR Study Group, 2011. "Residual Beta Cell Function in Newly Diagnosed Type 1 Diabetes after Treatment with Atorvastatin: The Randomized DIATOR Trial," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-8, March.
    • Handle: RePEc:plo:pone00:0017554
    DOI: 10.1371/journal.pone.0017554
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