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An Investigation of Genome-Wide Studies Reported Susceptibility Loci for Ulcerative Colitis Shows Limited Replication in North Indians

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Listed:
  • Garima Juyal
  • Pushplata Prasad
  • Sabyasachi Senapati
  • Vandana Midha
  • Ajit Sood
  • Devendra Amre
  • Ramesh C Juyal
  • Thelma BK

Abstract

Genome-Wide Association studies (GWAS) of both Crohn's Disease (CD) and Ulcerative Colitis (UC) have unearthed over 40 risk conferring variants. Recently, a meta-analysis on UC revealed several loci, most of which were either previously associated with UC or CD susceptibility in populations of European origin. In this study, we attempted to replicate these findings in an ethnically distinct north Indian UC cohort. 648 UC cases and 850 controls were genotyped using Infinium Human 660W-quad. Out of 59 meta-analysis index SNPs, six were not in the SNP array used in the study. Of the remaining 53 SNPs, four were found monomorphic. Association (p

Suggested Citation

  • Garima Juyal & Pushplata Prasad & Sabyasachi Senapati & Vandana Midha & Ajit Sood & Devendra Amre & Ramesh C Juyal & Thelma BK, 2011. "An Investigation of Genome-Wide Studies Reported Susceptibility Loci for Ulcerative Colitis Shows Limited Replication in North Indians," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-6, January.
    • Handle: RePEc:plo:pone00:0016565
    DOI: 10.1371/journal.pone.0016565
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    1. Pushplata Prasad & Ashok Kumar & Rajiva Gupta & Ramesh C Juyal & Thelma B. K., 2012. "Caucasian and Asian Specific Rheumatoid Arthritis Risk Loci Reveal Limited Replication and Apparent Allelic Heterogeneity in North Indians," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-5, February.

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