IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0014368.html
   My bibliography  Save this article

So Different, yet So Similar: Meta-Analysis and Policy Modeling of Willingness to Participate in Clinical Trials among Brazilians and Indians

Author

Listed:
  • Guilherme Zammar
  • Henrique Meister
  • Jatin Shah
  • Amruta Phadtare
  • Luciana Cofiel
  • Ricardo Pietrobon

Abstract

Background: With the global expansion of clinical trials and the expectations of the rise of the emerging economies known as BRICs (Brazil, Russia, India and China), the understanding of factors that affect the willingness to participate in clinical trials of patients from those countries assumes a central role in the future of health research. Methods: We conducted a systematic review and meta-analysis (SRMA) of willingness to participate in clinical trials among Brazilian patients and then we compared it with Indian patients (with results of another SRMA previously conducted by our group) through a system dynamics model. Results: Five studies were included in the SRMA of Brazilian patients. Our main findings are 1) the major motivation for Brazilian patients to participate in clinical trials is altruism, 2) monetary reimbursement is the least important factor motivating Brazilian patients, 3) the major barrier for Brazilian patients to not participate in clinical trials is the fear of side effects, and 4) Brazilian patients are more likely willing to participate in clinical trials than Indians. Conclusion: Our study provides important insights for investigators and sponsors for planning trials in Brazil (and India) in the future. Ignoring these results may lead to unnecessary fund/time spending. More studies are needed to validate our results and for better understanding of this poorly studied theme.

Suggested Citation

  • Guilherme Zammar & Henrique Meister & Jatin Shah & Amruta Phadtare & Luciana Cofiel & Ricardo Pietrobon, 2010. "So Different, yet So Similar: Meta-Analysis and Policy Modeling of Willingness to Participate in Clinical Trials among Brazilians and Indians," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-6, December.
    • Handle: RePEc:plo:pone00:0014368
    DOI: 10.1371/journal.pone.0014368
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014368
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014368&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0014368?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Hirsch, G. & Homer, J. & Evans, E. & Zielinski, A., 2010. "A system dynamics model for planning cardiovascular disease interventions," American Journal of Public Health, American Public Health Association, vol. 100(4), pages 616-622.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Pragyan Monalisa Sahoo & Himanshu Sekhar Rout & Mihajlo Jakovljevic, 2023. "Dynamics of Health Financing among the BRICS: A Literature Review," Sustainability, MDPI, vol. 15(16), pages 1-21, August.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. McGill, Elizabeth & Er, Vanessa & Penney, Tarra & Egan, Matt & White, Martin & Meier, Petra & Whitehead, Margaret & Lock, Karen & Anderson de Cuevas, Rachel & Smith, Richard & Savona, Natalie & Rutter, 2021. "Evaluation of public health interventions from a complex systems perspective: A research methods review," Social Science & Medicine, Elsevier, vol. 272(C).
    2. John Pastor Ansah & Shawn Tan Yi Wei & Tessa Lui Shi Min, 2020. "An evaluation of the impact of aggressive diabetes and hypertension management on chronic kidney diseases at the population level: a simulation analysis," System Dynamics Review, System Dynamics Society, vol. 36(4), pages 497-522, October.
    3. Stankov, Ivana & Useche, Andres Felipe & Meisel, Jose D. & Montes, Felipe & Morais, Lidia MO. & Friche, Amelia AL. & Langellier, Brent A. & Hovmand, Peter & Sarmiento, Olga Lucia & Hammond, Ross A. & , 2021. "From causal loop diagrams to future scenarios: Using the cross-impact balance method to augment understanding of urban health in Latin America," Social Science & Medicine, Elsevier, vol. 282(C).
    4. Negar Darabi & Niyousha Hosseinichimeh, 2020. "System dynamics modeling in health and medicine: a systematic literature review," System Dynamics Review, System Dynamics Society, vol. 36(1), pages 29-73, January.
    5. Chang, Angela Y. & Ogbuoji, Osondu & Atun, Rifat & Verguet, Stéphane, 2017. "Dynamic modeling approaches to characterize the functioning of health systems: A systematic review of the literature," Social Science & Medicine, Elsevier, vol. 194(C), pages 160-167.
    6. Reda Lebcir & Rifat Atun, 2021. "Resources management impact on neonatal services performance in the United Kingdom: A system dynamics modelling approach," International Journal of Health Planning and Management, Wiley Blackwell, vol. 36(3), pages 793-812, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0014368. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.