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Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus

Author

Listed:
  • Wei Bao
  • Fangfang Song
  • Xiangyang Li
  • Shuang Rong
  • Wei Yang
  • Muxun Zhang
  • Ping Yao
  • Liping Hao
  • Nianhong Yang
  • Frank B Hu
  • Liegang Liu

Abstract

Background: Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes mellitus (T2DM). Methods and Findings: 581 cases with newly-diagnosed T2DM (New-T2DM) and 611 comparison controls were recruited in this two-phase case-control study, comprising 420 cases and 429 controls collected in the first phase study and 161 cases and 182 controls in the second phase replication study. Analyses, using both separated data and combined data from the two-phase studies, show that plasma HO-1 concentrations were significantly increased in New-T2DM cases compared to controls (P

Suggested Citation

  • Wei Bao & Fangfang Song & Xiangyang Li & Shuang Rong & Wei Yang & Muxun Zhang & Ping Yao & Liping Hao & Nianhong Yang & Frank B Hu & Liegang Liu, 2010. "Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus," PLOS ONE, Public Library of Science, vol. 5(8), pages 1-7, August.
    • Handle: RePEc:plo:pone00:0012371
    DOI: 10.1371/journal.pone.0012371
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    Cited by:

    1. Simon Mitchell & Pedro Mendes, 2013. "A Computational Model of Liver Iron Metabolism," PLOS Computational Biology, Public Library of Science, vol. 9(11), pages 1-14, November.

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