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The Interaction between Coagulation Factor 2 Receptor and Interleukin 6 Haplotypes Increases the Risk of Myocardial Infarction in Men

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  • Bruna Gigante
  • Anna M Bennet
  • Karin Leander
  • Max Vikström
  • Ulf de Faire

Abstract

The aim of the study was to investigate if the interaction between the coagulation factor 2 receptor (F2R) and the interleukin 6 (IL6) haplotypes modulates the risk of myocardial infarction (MI) in the Stockholm Heart Epidemiology Program (SHEEP). Seven SNPs at the F2R locus and three SNPs at the IL6 locus were genotyped. Haplotypes and haplotype pairs (IL6*F2R) were generated. A logistic regression analysis was performed to analyze the association of the haplotypes and haplotype pairs with the MI risk. Presence of an interaction between the two haplotypes in each haplotype pair was calculated using two different methods: the statistical, on a multiplicative scale, which includes the cross product of the two factors into the logistic regression model; the biological, on an additive scale, which evaluates the relative risk associated with the joint presence of both factors. The ratio between the observed and the predicted effect of the joint exposure, the synergy index (S), indicates the presence of a synergy (S>1) or of an antagonism (S

Suggested Citation

  • Bruna Gigante & Anna M Bennet & Karin Leander & Max Vikström & Ulf de Faire, 2010. "The Interaction between Coagulation Factor 2 Receptor and Interleukin 6 Haplotypes Increases the Risk of Myocardial Infarction in Men," PLOS ONE, Public Library of Science, vol. 5(6), pages 1-5, June.
    • Handle: RePEc:plo:pone00:0011300
    DOI: 10.1371/journal.pone.0011300
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    Cited by:

    1. Na Li & Runmei Liu & Hongxia Zhai & Liang Li & Yaxin Yin & Jinjin Zhang & Yunfeng Xia, 2014. "Polymorphisms of the LTA Gene May Contribute to the Risk of Myocardial Infarction: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-13, March.

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