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Replication of Association between ADAM33 Polymorphisms and Psoriasis

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Listed:
  • Valérie Siroux
  • Emmanuelle Bouzigon
  • Marie-Hélène Dizier
  • Isabelle Pin
  • Florence Demenais
  • Francine Kauffmann
  • for the EGEA cooperative group

Abstract

Polymorphisms in ADAM33, the first gene identified in asthma by positional cloning, have been recently associated with psoriasis. No replication study of this association has been published so far. Data available in the French EGEA study (Epidemiological study on Genetics and Environment of Asthma, bronchial hyperresponsivensess and Atopy) give the opportunity to attempt to replicate the association between ADAM33 and psoriasis in 2002 individuals. Psoriasis (n = 150) has been assessed by questionnaire administered by an interviewer and a sub-sample of subjects with early-onset psoriasis (n = 74) has been identified based on the age of the subjects at time of interview (

Suggested Citation

  • Valérie Siroux & Emmanuelle Bouzigon & Marie-Hélène Dizier & Isabelle Pin & Florence Demenais & Francine Kauffmann & for the EGEA cooperative group, 2008. "Replication of Association between ADAM33 Polymorphisms and Psoriasis," PLOS ONE, Public Library of Science, vol. 3(6), pages 1-6, June.
  • Handle: RePEc:plo:pone00:0002448
    DOI: 10.1371/journal.pone.0002448
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    References listed on IDEAS

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    1. Roberto Lande & Josh Gregorio & Valeria Facchinetti & Bithi Chatterjee & Yi-Hong Wang & Bernhard Homey & Wei Cao & Yui-Hsi Wang & Bing Su & Frank O. Nestle & Tomasz Zal & Ira Mellman & Jens-Michael Sc, 2007. "Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide," Nature, Nature, vol. 449(7162), pages 564-569, October.
    2. Paul Van Eerdewegh & Randall D. Little & Josée Dupuis & Richard G. Del Mastro & Kathy Falls & Jason Simon & Dana Torrey & Sunil Pandit & Joyce McKenny & Karen Braunschweiger & Alison Walsh & Ziying Li, 2002. "Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness," Nature, Nature, vol. 418(6896), pages 426-430, July.
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