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Commercial Nucleic-Acid Amplification Tests for Diagnosis of Pulmonary Tuberculosis in Respiratory Specimens: Meta-Analysis and Meta-Regression

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  • Daphne I Ling
  • Laura L Flores
  • Lee W Riley
  • Madhukar Pai

Abstract

Background: Hundreds of studies have evaluated the diagnostic accuracy of nucleic-acid amplification tests (NAATs) for tuberculosis (TB). Commercial tests have been shown to give more consistent results than in-house assays. Previous meta-analyses have found high specificity but low and highly variable estimates of sensitivity. However, reasons for variability in study results have not been adequately explored. We performed a meta-analysis on the accuracy of commercial NAATs to diagnose pulmonary TB and meta-regression to identify factors that are associated with higher accuracy. Methodology/Principal Findings: We identified 2948 citations from searching the literature. We found 402 articles that met our eligibility criteria. In the final analysis, 125 separate studies from 105 articles that reported NAAT results from respiratory specimens were included. The pooled sensitivity was 0.85 (range 0.36–1.00) and the pooled specificity was 0.97 (range 0.54–1.00). However, both measures were significantly heterogeneous (p

Suggested Citation

  • Daphne I Ling & Laura L Flores & Lee W Riley & Madhukar Pai, 2008. "Commercial Nucleic-Acid Amplification Tests for Diagnosis of Pulmonary Tuberculosis in Respiratory Specimens: Meta-Analysis and Meta-Regression," PLOS ONE, Public Library of Science, vol. 3(2), pages 1-11, February.
  • Handle: RePEc:plo:pone00:0001536
    DOI: 10.1371/journal.pone.0001536
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    References listed on IDEAS

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    1. Benjamin Littenberg & Lincoln E. Moses, 1993. "Estimating Diagnostic Accuracy from Multiple Conflicting Reports," Medical Decision Making, , vol. 13(4), pages 313-321, December.
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    Cited by:

    1. Anna H van’t Hoog & Frank Cobelens & Anna Vassall & Sanne van Kampen & Susan E Dorman & David Alland & Jerrold Ellner, 2013. "Optimal Triage Test Characteristics to Improve the Cost-Effectiveness of the Xpert MTB/RIF Assay for TB Diagnosis: A Decision Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-11, December.

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