Quantifying sociodemographic heterogeneities in the distribution of Aedes aegypti among California households

The spread of Aedes aegypti in California and other regions of the U.S. has increased the need to understand the potential for local chains of Ae. aegypti-borne virus transmission, particularly in arid regions of the state where the ecology of these mosquitoes is less understood. For public health and vector control programs, it is helpful to know whether variation in risk of local transmission can be attributed to socio-demographic factors that could help to target surveillance and control programs. Socio-demographic factors have been shown to influence transmission risk of dengue virus outside the U.S. by modifying biting rates and vector abundance. In regions of the U.S. where Ae. aegypti have recently invaded and where residential areas are structured differently than those in the tropics where Ae. aegypti are endemic, it is unclear how socio-demographic factors modify the abundance of Ae. aegypti populations. Understanding heterogeneities among households in Ae. aegypti abundance will provide a better understanding of local vectorial capacity and is an important component of understanding risk of local Ae. aegypti-borne virus transmission. We conducted a cross-sectional study in Los Angeles County, California during summer 2017 to understand the causes of variation in relative abundance of Ae. aegypti among households. We surveyed 161 houses, representing a wide range of incomes. Surveys consisted of systematic adult mosquito collections, inspections of households and properties, and administration of a questionnaire in English or Spanish. Adult Ae. aegypti were detected at 72% of households overall and were found indoors at 12% of households. An average of 3.1 Ae. aegypti were collected per household. Ae. aegypti abundance outdoors was higher in lower-income neighborhoods and around older households with larger outdoor areas, greater densities of containers with standing water, less frequent yard maintenance, and greater air-conditioner use. We also found that Aedes aegypti abundance indoors was higher in households that had less window and door screening, less air-conditioner usage, more potted plants indoors, more rain-exposed containers around the home, and lower neighborhood human population densities. Our results indicate that, in the areas of southern California studied, there are behavioral and socio-demographic determinants of Ae. aegypti abundance, and that low-income households could be at higher risk for exposure to Ae. aegypti biting and potentially greater risk for Zika, dengue, and chikungunya virus transmission if a local outbreak were to occur.Author summary: Understanding the factors that influence the spread and population growth of Aedes aegypti, the primary mosquito vector of Zika, dengue, and chikungunya viruses, will aid vector control and public health agencies to identify the communities most at risk for Ae. aegypti biting. This study found associations between increased Ae. aegypti abundance and mappable socioeconomic variables that can serve as a basis for targeted control strategies. We describe neighborhood- and household-scale risk factors associated with increased Ae. aegypti abundance in Los Angeles, California, an area that historically has had a relatively high number of travelers return home that are infected with Zika and dengue viruses. Our results show that Ae. aegypti is more abundant in lower income communities in Los Angeles and that several household, behavioral, and socio-demographic characteristics are associated with increased abundance of Ae. aegypti. Our findings have the potential to help vector control agencies identify communities at risk of increased household Ae. aegypti abundance and develop community-specific interventions to minimize household infestations.