IDEAS home Printed from https://ideas.repec.org/a/plo/pntd00/0008298.html
   My bibliography  Save this article

Safety and efficacy of co-administered diethylcarbamazine, albendazole and ivermectin during mass drug administration for lymphatic filariasis in Haiti: Results from a two-armed, open-label, cluster-randomized, community study

Author

Listed:
  • Christine L Dubray
  • Anita D Sircar
  • Valery Madsen Beau de Rochars
  • Joshua Bogus
  • Abdel N Direny
  • Jean Romuald Ernest
  • Carl R Fayette
  • Charles W Goss
  • Marisa Hast
  • Kobie O’Brian
  • Guy Emmanuel Pavilus
  • Daniel Frantz Sabin
  • Ryan E Wiegand
  • Gary J Weil
  • Jean Frantz Lemoine

Abstract

In Haiti, 22 communes still require mass drug administration (MDA) to eliminate lymphatic filariasis (LF) as a public health problem. Several clinical trials have shown that a single oral dose of ivermectin (IVM), diethylcarbamazine (DEC) and albendazole (ALB) (IDA) is more effective than DEC plus ALB (DA) for clearing Wuchereria bancrofti microfilariae (Mf). We performed a cluster-randomized community study to compare the safety and efficacy of IDA and DA in an LF-endemic area in northern Haiti. Ten localities were randomized to receive either DA or IDA. Participants were monitored for adverse events (AE), parasite antigenemia, and microfilaremia. Antigen-positive participants were retested one year after MDA to assess treatment efficacy. Fewer participants (11.0%, 321/2917) experienced at least one AE after IDA compared to DA (17.3%, 491/2844, P

Suggested Citation

  • Christine L Dubray & Anita D Sircar & Valery Madsen Beau de Rochars & Joshua Bogus & Abdel N Direny & Jean Romuald Ernest & Carl R Fayette & Charles W Goss & Marisa Hast & Kobie O’Brian & Guy Emmanuel, 2020. "Safety and efficacy of co-administered diethylcarbamazine, albendazole and ivermectin during mass drug administration for lymphatic filariasis in Haiti: Results from a two-armed, open-label, cluster-r," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(6), pages 1-21, June.
    • Handle: RePEc:plo:pntd00:0008298
    DOI: 10.1371/journal.pntd.0008298
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008298
    Download Restriction: no
    File URL: https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0008298&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pntd.0008298?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pntd00:0008298. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosntds (email available below). General contact details of provider: https://journals.plos.org/plosntds/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.