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The Babesia observational antibody (BAOBAB) study: A cross-sectional evaluation of Babesia in two communities in Kilosa district, Tanzania

Author

Listed:
  • Evan M Bloch
  • Zakayo Mrango
  • Mabula Kasubi
  • Jerusha Weaver
  • Aleksandra Mihailovic
  • Beatriz Munoz
  • Anna Weimer
  • Andrew Levin
  • Laura Tonnetti
  • Jeffrey M Linnen
  • Vanessa Brès
  • Douglas E Norris
  • Giovanna Carpi
  • Sheila K West

Abstract

Background: Babesia, a tick-borne genus of intraerythrocytic parasites, is understudied in humans outside of established high-endemic areas. There is a paucity of data on Babesia in Africa, despite evidence that it is regionally present. A pilot study suggested that Babesia was present in a rural district of Tanzania. Methodology/Principal findings: A cross-sectional study was conducted July-August 2017: residents in a case hamlet that had clustering of subjects with high signal-to-cut off (S/CO) ratios for antibodies against B. microti in the pilot study, and a control hamlet that had lacked significant signal, were evaluated for B. microti. Subjects aged ≥15yrs (n = 299) underwent clinical evaluation and household inspections; 10ml whole blood was drawn for Babesia transcription mediated amplification (TMA), B. microti indirect fluorescent antibody testing (IFA) and rapid diagnostic testing (RDT) for Plasmodium spp. Subjects aged

Suggested Citation

  • Evan M Bloch & Zakayo Mrango & Mabula Kasubi & Jerusha Weaver & Aleksandra Mihailovic & Beatriz Munoz & Anna Weimer & Andrew Levin & Laura Tonnetti & Jeffrey M Linnen & Vanessa Brès & Douglas E Norris, 2019. "The Babesia observational antibody (BAOBAB) study: A cross-sectional evaluation of Babesia in two communities in Kilosa district, Tanzania," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 13(8), pages 1-15, August.
    • Handle: RePEc:plo:pntd00:0007632
    DOI: 10.1371/journal.pntd.0007632
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