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Toxoplasmosis seroprevalence in rheumatoid arthritis patients: A systematic review and meta-analysis

Author

Listed:
  • Zahra Hosseininejad
  • Mehdi Sharif
  • Shahabeddin Sarvi
  • Afsaneh Amouei
  • Seyed Abdollah Hosseini
  • Tooran Nayeri Chegeni
  • Davood Anvari
  • Reza Saberi
  • Shaban Gohardehi
  • Azadeh Mizani
  • Mitra Sadeghi
  • Ahmad Daryani

Abstract

Background: Toxoplasmosis is a cosmopolitan infection caused by an intracellular obligatory protozoan, Toxoplasma gondii. Infection to this parasite in immunocompetent patients is usually asymptomatic, but today it is believed that the infection can be a risk factor for a variety of diseases, including rheumatoid arthritis (RA). RA is an autoimmune disease and the most common type of inflammatory arthritis that is a major cause of disability. The aim of this systematic review and meta-analysis was to address the association between RA and toxoplasmosis in light of the available research. Methods: Based on the keywords, a systematic search of eight databases was conducted to retrieve the relevant English-language articles. Then, the studies were screened based on the inclusion and exclusion criteria. The random effect model was used to calculate the odds ratio (OR) using forest plot with 95% confidence interval (CI). Results: Overall, 4168 Individual, extracted from 9 articles were included for systematic review evaluation, with 1369 RA patients (46% positive toxoplasmosis) and 2799 individuals as controls (21% positive toxoplasmosis). Then, eight articles (10 datasets) were used for meta-analysis (1244 rheumatoid arthritis patients and 2799 controls). By random effect model, the combined OR was 3.30 (95% CI: 2.05 to 5.30) with P

Suggested Citation

  • Zahra Hosseininejad & Mehdi Sharif & Shahabeddin Sarvi & Afsaneh Amouei & Seyed Abdollah Hosseini & Tooran Nayeri Chegeni & Davood Anvari & Reza Saberi & Shaban Gohardehi & Azadeh Mizani & Mitra Sadeg, 2018. "Toxoplasmosis seroprevalence in rheumatoid arthritis patients: A systematic review and meta-analysis," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 12(6), pages 1-13, June.
    • Handle: RePEc:plo:pntd00:0006545
    DOI: 10.1371/journal.pntd.0006545
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    Cited by:

    1. Sharmin Sultana & Gilberto González-Parra & Abraham J. Arenas, 2023. "Mathematical Modeling of Toxoplasmosis in Cats with Two Time Delays under Environmental Effects," Mathematics, MDPI, vol. 11(16), pages 1-20, August.

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